Deaths burden of laryngeal cancer attributable to occupational exposure in the male working age population

Findings from global burden of disease study 2021

Bibliographic Data

ID22085121
AuthorsDonghai Wang (0000-0001-7261-8510, Suizhou Central Hospital), Sen Yang (0000-0001-9953-4499, Suizhou Central Hospital), Wenxing Yu (Suizhou Central Hospital), Zixuan Tang (0000-0002-7394-8666, Suizhou Central Hospital), Qin Wang (0000-0003-4488-3039, Suizhou Central Hospital), Mingzhu Fang (0000-0002-2596-4266, Xichang University, corresponding author), Chunyan Li (0000-0001-9388-1799, Suizhou Central Hospital, corresponding author)
Year2025
Volume13
Pages1605654-1605654
Publication date2025-06-27
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2025.1605654
PMID40655213
OpenAlexW4411706404
LanguageEN
References cited27

Objectives: Laryngeal cancer (LC) is a major health threat to the male working-age population, with occupational exposures (asbestos and sulfuric acid) being key risk factors. However, the deaths burden of LC attributable to occupational exposure in this population remains unclear. This study analyzes the deaths burden from 1990 to 2021 using Global Burden of Disease (GBD) data, providing insights for optimizing prevention strategies. Methods: Data from GBD 2021 database were used to calculate age-standardized death rates (ASDR) and estimated annual percent changes (EAPC). Decomposition analysis and Bayesian age-period-cohort (BAPC) models were applied to assess trends, drivers, and predict future trends to 2040. Frontier analysis exploring the relationship between SDI and ASDR for 204 countries and territories. Results: Globally, deaths burden of LC attributable to occupational exposures exhibited divergent trends from 1990 to 2021. Asbestos-related deaths decreased by 22% (533.6 cases in 2021; ASDR 0.02/100,000, 95% CI 0.01-0.04), with an EAPC of -3.23% (95% CI -3.32 to -3.14). Sulfuric acid-associated mortality increased by 16.19% (2,131.2 cases; ASDR 0.09/100,000, 95% CI 0.04-0.16), though with an EAPC decline of -1.90% (-1.98 to -1.82), suggesting improving age-standardized rates. Regional disparities were striking: High-SDI regions showed elevated asbestos burdens (Western Europe ASDR 0.06 vs. global 0.02), while middle-SDI regions dominated sulfuric acid mortality (South Asia ASDR 0.18 vs. global 0.09). Decomposition analysis revealed distinct drivers - asbestos burden growth (415% from epidemiological factors) reflected latency effects of historical exposures, whereas sulfuric acid increases stemmed from population expansion (336%) and aging (148%). Projections to 2040 indicate continued divergence: asbestos-related deaths are predicted to decline to 372.8 cases (ASDR 0.011/100,000), while sulfuric acid-associated mortality may rise to 2,543.8 cases (ASDR 0.078/100,000), with middle/low-SDI regions accounting for 78% of sulfuric acid burden. Conclusion: Laryngeal cancer burden attributable to occupational exposure shows a contrasting trend with asbestos-related deaths appearing to decrease while sulfuric acid-related cases are rising. High-SDI regions face legacy asbestos risks, while middle and low-SDI regions are increasingly exposed to sulfuric acid. Targeted prevention strategies are needed, high-SDI regions should focus on asbestos risk management, and middle/low-SDI regions need to strengthen industrial protections, promote alternative materials, and enhance screening

Asbestos · Attributable risk · Disease burden · Environmental health · Population · Demography · Esophageal Cancer Research and Treatment · Head and Neck Cancer Studies · Medicine · Occupational and environmental lung diseases

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