Mental health among healthcare workers during Covid-19
A study to oversee the impact of the risk perception and relationship with inflammation from blood-based extracellular vesicles
Bibliographic Data
| ID | 22085201 |
|---|---|
| Authors | Coraline Canivet (Centre hospitalier universitaire de Québec), Thalie Hébert (Centre hospitalier universitaire de Québec), Eric Boilard (0000-0001-6319-6432, Université Laval), Charles M Morin (0000-0002-8649-8895, Université Laval), Jessica Deslauriers (0000-0003-0757-5328, Centre hospitalier universitaire de Québec, corresponding author) |
| Year | 2025 |
| Volume | 13 |
| Pages | 1560129-1560129 |
| Publication date | 2025-08-21 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2025.1560129 |
| PMID | 40917429 |
| OpenAlex | W4413405967 |
| Language | EN |
| References cited | 65 |
Introduction: Preventive measures have been implemented in hospitals during COVID-19, but how these guidelines affected mental health among healthcare workers (HCWs) remains to be determined. On another note, reliable psychological and blood-based markers are needed to promptly identify HCWs at-risk to develop distress. Extracellular vesicles (EVs) originating from brain cross the blood-brain barrier and are detectable in blood, giving them a highly valuable potential for biomarker discovery. In HCWs with or without psychological distress, we investigated how perceived stress during COVID-19 impacted mental health. We then longitudinally evaluated the inflammatory cargo from neuron-, astrocyte-, and microglial-derived EVs that may be associated with psychological distress. Methods: = 15) completed questionnaires for perception of risk, COVID-19-specific posttraumatic symptomatology, psychological distress and burnout, as well as sleep quality. Blood was collected at each visit to characterizing inflammation from brain-derived EVs. Multiple regressions were conducted for all psychological/biological parameters based on the HCWs' final score for psychological distress. Results: Onset of psychological distress was associated early hyperarousal. Moreover, severe distress was associated with increased astrocyte-specific levels of anti-inflammatory interleukin-10 and pro-inflammatory interferon-ɣ. Discussion: Our findings-that need to be replicated in larger studies-suggest that early hyperarousal may be predictive of later onset of psychological distress in HCWs. They also unravel a novel area of biomarker discovery study in psychiatry as inflammation from brain-derived EVs could help targeting "at-risk" individuals
2019-20 coronavirus outbreak · Biology · Disease · Extracellular vesicles · Health care · Inflammation · Mental health · Outbreak · Pathology · Perception · Psychiatry · COVID-19 and Mental Health · Long-Term Effects of COVID-19 · Medicine · Neuroscience · Psychology · Tryptophan and brain disorders · Immunology
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| Highly cited | No |
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