Clinical characteristics and risk factors of Hepatitis E virus infection in Zhejiang Province
A multicenter case–control study
Bibliographic Data
| ID | 22085281 |
|---|---|
| Authors | Yijuan Chen (0000-0001-7725-3629, Zhejiang Center for Disease Control and Prevention), Jian Gao (0000-0001-6659-5770, Zhejiang Center for Disease Control and Prevention), Wanwan Sun (0000-0003-2268-7715, Zhejiang Center for Disease Control and Prevention), Weiping Zhu (0000-0001-7714-350X, Xinjiang Uygur Autonomous Region Disease Prevention and Control Center), Pingping Wang (0000-0001-5480-6382), Xiaobin Ren (0009-0008-0297-1990, Hangzhou Center for Disease Control and Prevention), Yumeng Wu (0000-0001-7049-135X), Jianli Zhang (0000-0002-3194-0375), Ziping Miao (0000-0002-1037-620X, Zhejiang Center for Disease Control and Prevention, corresponding author) |
| Year | 2024 |
| Volume | 12 |
| Pages | 1417556-1417556 |
| Publication date | 2024-07-05 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1417556 |
| PMID | 39035188 |
| OpenAlex | W4400369388 |
| Language | EN |
| References cited | 19 |
Introduction: Hepatitis E (HE), caused by the Hepatitis E virus (HEV), is a significant cause of acute viral hepatitis globally and a major public health concern, particularly in specific high-prevalence areas in China, which have diverse transmission routes and regional differences. Identifying the primary risk factors for HE transmission is essential to develop targeted interventions for vulnerable populations. Methods: This study employed a 1:1 matched case-control methodology, using a standardized questionnaire complemented by medical records for data validation. Results: Among the 442 HE cases and 428 healthy controls, the case group had a higher prevalence of fatigue (46.21%) and loss of appetite (43.84%) compared to the control group. Furthermore, liver function indicators were significantly higher in the case group, with an average alanine aminotransferase (ALT) level of 621.94 U/L and aspartate aminotransferase (AST) level of 411.53 U/L. Severe HE patients were predominantly male, with significantly increased ALT and AST levels reaching 1443.81 U/L and 862.31 U/L respectively, along with a higher incidence of fatigue (90%) and loss of appetite (75%). Multifactorial analysis indicated that frequent dining out (OR = 2.553, 95%CI:1.686-3.868), poor hygiene conditions (OR = 3.889, 95%CI:1.399-10.807), and comorbid chronic illnesses (OR = 2.275, 95%CI:1.616-3.202) were risk factors for HE infection; conversely, good hygiene practices were protective factors against HE infection (OR = 0.698, 95%CI:0.521-0.934). Conclusion: In conclusion, HE infection in Zhejiang Province is closely associated with dietary habits and environmental hygiene, and individuals with chronic diseases or co-infections are at increased risk. This highlights the need for targeted health education to reduce the incidence of HE among these populations
Alanine aminotransferase · Alanine transaminase · Cross-sectional study · Hygiene · Liver function · Pathology · Psychological intervention · Hepatitis B Virus Studies · Hepatitis Viruses Studies and Epidemiology · Medicine · Travel-related health issues · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |