Association Between Dietary Inflammatory Index and Sex Hormone Binding Globulin and Sex Hormone in U.S. Adult Females
Bibliographic Data
| ID | 22085543 |
|---|---|
| Authors | Nuozhou Liu (0000-0003-4416-8510, Sichuan University), Ying Feng (0009-0006-7838-3103, West China Medical Center of Sichuan University), Xinyao Luo (Sichuan University), Xue Ma (0009-0007-5128-8007, Sichuan University, corresponding author), Fang Ma (0009-0007-9446-9318, Sichuan University, corresponding author) |
| Year | 2022 |
| Volume | 10 |
| Pages | 802945-802945 |
| Publication date | 2022-04-15 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.802945 |
| PMID | 35493382 |
| OpenAlex | W4224107426 |
| Language | EN |
| References cited | 53 |
Context It is still unknown whether the dietary inflammatory index (DII) is associated with sex hormones and sex hormone binding globulin (SHBG) in adult women. Objective This study examined the association between DII and sex hormones and SHBG in U.S. adult women. Design and Participants This was a cross-sectional study. A total of 2,092 female participants (age ≥ 20) from the 2013–2016 National Health and Nutrition Examination Survey were enrolled. Dietary inflammatory potential was assessed by DII based on 24-h dietary recall. SHBG was assessed using immuno-antibodies and chemo-luminescence, whereas sex hormones were measured by ID-LC–MS/MS. Results The average DII was 0.21 ± 1.68, ranging from −4.54 (most anti-inflammatory) to 4.28 (most pro-inflammatory). After adjusting all covariates, a per-unit DII increase in DII tertile 3 was related to an 8.05 nmol/L SHBG decrease compared to DII tertile 1 ( P = 0.0366). Subgroup analysis stratified by perimenopausal period found that this negative association remained strong but only existed in women before (β = −3.71, 95% CI: −7.43, −0.12, P = 0.0423) the perimenopausal period. Interaction terms were added to both subgroup analyses and found no significant heterogeneity among different body mass index (BMI) or perimenopausal groups ( P > 0.05). Treshold analyses showed that the association of age with SHBG was an inverted U -shaped curve (inflection point: age = 50 yrs). Conclusion A proinflammatory diet caused decreased SHBG. However, more well-designed studies are still needed to validate and verify the causal relationship between DII and sex hormones and SHBG
Androgen · Biology · Body mass index · Hormone · Inflammation · National Health and Nutrition Examination Survey · Population · Proinflammatory cytokine · Sex hormone-binding globulin · Adipokines, Inflammation, and Metabolic Diseases · Hormonal and reproductive studies · Medicine · Nutritional Studies and Diet · Endocrinology · Internal Medicine · Physiology
| Citation velocity | historical |
|---|---|
| Highly cited | No |