The efficacy and acceptability of pharmacological monotherapies and e-cigarette on smoking cessation
A systemic review and network meta-analysis
Bibliographic Data
| ID | 22085561 |
|---|---|
| Authors | Yajing Meng (0000-0002-9688-0000, Sichuan University), Sike Xiang (Sichuan University), Lang Qu (Sinai Hospital, corresponding author), Ying Li (0000-0003-0678-9535, West China Medical Center of Sichuan University, corresponding author) |
| Year | 2024 |
| Volume | 12 |
| Pages | 1361186-1361186 |
| Publication date | 2024-05-22 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1361186 |
| PMID | 38841681 |
| OpenAlex | W4398218027 |
| Language | EN |
| References cited | 74 |
Background and aims: Several pharmacological interventions, such as nicotine replacement therapy (NRT), varenicline, and bupropion, have been approved for clinical use of smoking cessation. E-cigarettes (EC) are increasingly explored by many RCTs for their potentiality in smoking cessation. In addition, some RCTs are attempting to explore new drugs for smoking cessation, such as cytisine. This network meta-analysis (NMA) aims to investigate how these drugs and e-cigarettes compare regarding their efficacy and acceptability. Materials and methods: This systematic review and NMA searched all clinical studies on smoking cessation using pharmacological monotherapies or e-cigarettes published from January 2011 to May 2022 using MEDLINE, COCHRANE Library, and PsychINFO databases. NRTs were divided into transdermal (TDN) and oronasal nicotine (ONN) by administrative routes, thus 7 network nodes were set up for direct and indirect comparison. Two different indicators measured the efficacy: prevalent and continuous smoking abstinence. The drop-out rates measured the acceptability. Results: The final 40 clinical studies included in this study comprised 77 study cohorts and 25,889 participants. Varenicline is more effective intervention to assist in smoking cessation during 16-32 weeks follow-up, and is very likely to prompt dropout. Cytisine shows more effectiveness in continuous smoking cessation but may also lead to dropout. E-cigarettes and oronasal nicotine are more effective than no treatment in encouraging prevalent abstinence, but least likely to prompt dropout. Finally, transdermal nicotine delivery is more effective than no treatment in continuous abstinence, with neither significant effect on prevalent abstinence nor dropout rate. Conclusion: This review suggested and agreed that Varenicline, Cytisine and transdermal nicotine delivery, as smoking cessation intervention, have advantages and disadvantages. However, we had to have reservations about e-cigarettes as a way to quit smoking in adolescents
Abstinence · Bupropion · Cochrane Library · Cytisine · Meta-analysis · Nicotine · Nicotine replacement therapy · Psychiatry · Smoking cessation · Tics · Varenicline · Medicine · Nicotinic Acetylcholine Receptors Study · Reliability and Agreement in Measurement · Smoking Behavior and Cessation · Internal Medicine
Electronic cigarettes for smoking cessation
Biochemical Verification of Tobacco Use and Abstinence
Association Between Initial Use of e-Cigarettes and Subsequent Cigarette Smoking Among Adolescents and Young Adults
The rise of e-cigarettes, pod mod devices, and Juul among youth
EffiCiency and Safety of an eLectronic cigAreTte (Eclat) as Tobacco Cigarettes Substitute
| Citation velocity | historical |
|---|---|
| Highly cited | No |