Association between serum and urinary environmental metal levels and major depressive disorder
A study based on logistic regression and quantile regression
Bibliographic Data
| ID | 22085563 |
|---|---|
| Authors | Qixuan Sun (0009-0008-0079-7167, Southwest University), Haiyang Ding (Southwest University), Chenxuan Lu (Southwest University), Lailai Yan (0000-0002-8554-9689, Peking University, corresponding author), Bing Cao (0000-0003-3588-972X, Southwest University, corresponding author) |
| Year | 2024 |
| Volume | 12 |
| Pages | 1450983-1450983 |
| Publication date | 2024-08-29 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1450983 |
| PMID | 39228853 |
| OpenAlex | W4402016079 |
| Language | EN |
| References cited | 49 |
Background Major depressive disorder (MDD) is a prevalent mental disorder globally. Increasing evidence suggests that Environmental Metal (EM) play a crucial role in MDD. Therefore, this study investigated the roles of barium (Ba), cesium (Cs), nickel (Ni), manganese (Mn), lead (Pb), mercury (Hg), cadmium (Cd), and tin (Sn) in the etiology of MDD. Methods The study included 72 MDD patients and 75 healthy controls (HCs) from the Second People’s Hospital of Zhumadian, China. Inductively coupled plasma mass spectrometer (ICP-MS) measured the metal levels in serum and urine samples from both groups. Results Significant differences in serum and urine levels of EMs were observed between MDD patients and HCs. After adjusting for age, gender, and BMI, logistic regression and quantile regression models revealed significant associations between EMs and MDD. In serum samples, higher Sn levels (OR = 1.22, p = 0.044) increased MDD risk, whereas higher Cs levels (OR = 0.02, p < 0.001), Cd (OR = 0.06, p = 0.047), and Mn (OR = 0.54, p = 0.016) decreased MDD risk. In urine samples, higher Ba levels (OR = 0.94, p = 0.015), Ni (OR = 0.87, p = 0.0024), Sn (OR = 1.62, p < 0.001), and Mn (OR = 0.77, p = 0.037) were significantly associated with MDD. Sn significantly positively predicted HAMD-24 scores at the 0.50 and 0.75 quantiles (β = 0.96, p = 0.018; β = 1.25, p = 0.008) as did Pb (β = 5.15, p = 0.001; β = 4.19, p = 0.004). Ba positively predicted depressive symptoms across all quantiles (all p < 0.05). Hg positively predicted HAMD-24 scores at the 0.50 quantile (β = 9.20, p = 0.050). Conclusion These findings underscore EMs’ importance in depression, aiding in targeted interventions for varying degrees of depression and necessitating future studies to clarify causality and mechanisms
Cross-sectional regression · Econometrics · Environmental health · Logistic regression · Major depressive disorder · Polynomial regression · Psychiatry · Quantile regression · Regression · Regression analysis · Sociology · Statistics · Clinical Psychology · Demography · Heavy Metal Exposure and Toxicity · Heavy Metals in Plants · Magnesium in Health and Disease · Mathematics · Medicine · Psychology · Internal Medicine
Relationships between urinary metals concentrations and cognitive performance among U.S. older people in NHANES 2011–2014
Using Quantile Regression to Estimate Intervention Effects Beyond the Mean
Symptoms of Major Depressive Disorder and Their Impact on Psychosocial Functioning in the Different Phases of the Disease
Systematic reviews and meta-analyses on major depressive disorder
Serum and urinary essential trace elements in association with major depressive disorders
DSM-5 Criteria and Depression Severity
| Citation velocity | historical |
|---|---|
| Highly cited | No |