The association between multimorbidity patterns and physical frailty among middle-aged and older community-dwelling adults
The mediating role of depressive symptoms
Bibliographic Data
| ID | 22085582 |
|---|---|
| Authors | Yuhan Geng (Chinese PLA General Hospital), Ming Zhou (0000-0002-5701-1996, Chinese PLA General Hospital), Yangxiaoxue Liu (Chinese PLA General Hospital), Tianshu Zhao (0000-0002-1460-2569, Chinese PLA General Hospital), Jiali Zhang (0000-0001-6257-063X, Chinese PLA General Hospital), Xin Min (0000-0003-3953-2699, Chinese PLA General Hospital), Min Xin, Wenxin Wang (0000-0002-7274-1970, Chinese PLA General Hospital), Gongzi Zhang (Chinese PLA General Hospital, corresponding author), Liping Huang (0000-0003-3073-7698, Chinese PLA General Hospital, corresponding author) |
| Year | 2025 |
| Volume | 13 |
| Pages | 1527982-1527982 |
| Publication date | 2025-05-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2025.1527982 |
| PMID | 40376054 |
| OpenAlex | W4410015595 |
| Language | EN |
| References cited | 70 |
Background: This study aimed to investigate the association between multimorbidity and frailty, and the potential mediating role of depressive symptoms in Chinese middle-aged and older community-dwelling adults. Methods: We selected a total of 5,232 adults with two or more chronic diseases from the China Health and Retirement Longitudinal Study (CHARLS) database. Clusters of participants with similar multimorbidity patterns were identified through fuzzy c-means cluster analyses. The cross-sectional association between multimorbidity and frailty was measured through logistic regression analyses. Mediation analysis was applied to examine direct and indirect associations within the counterfactual framework. Results: = 0.042). Notably, in adults aged 60 years and older, this mediation accounted for 69.84% of the total effect, surpassing the direct impact of multimorbidity on frailty. Among individuals with economic support (0.020, 95% CI: 0.002-0.040), high school education (0.062, 95% CI: 0.007-0.120), and no alcohol consumption (0.024, 95% CI: 0.003-0.050), depression entirely mediated the impact of comorbidities. Conclusion: This study reveals strong links between specific multimorbidity patterns and physical frailty, with depression significantly mediating these effects, particularly in certain populations. Findings emphasize tailored mental health interventions' necessity in specific groups
Anxiety · Comorbidity · Depressive symptoms · Multimorbidity · Psychiatry · Chronic Disease Management Strategies · Frailty in Older Adults · Medicine · Primary Care and Health Outcomes · Psychology · Gerontology
Psychometric properties of a short form of the Center for Epidemiologic Studies Depression (CES-D-10) scale for screening depressive symptoms in healthy community dwelling older adults
The path to healthy ageing in China
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The Timed “Up & Go”
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Clinical diagnosis of depression in primary care
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| Citation velocity | historical |
|---|---|
| Highly cited | No |