Case report
Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11
Bibliographic Data
| ID | 22085795 |
|---|---|
| Authors | Wei Gao (0000-0003-3999-7146, Sichuan University), Wenyu Li (0000-0003-0218-589X, Sichuan University), Qian Zheng (0000-0002-3466-0870, Sichuan University), Nenggang Jiang (0009-0003-0261-927X, Sichuan University), Huairong Tang (0000-0003-0173-4658, Sichuan University, corresponding author) |
| Year | 2023 |
| Volume | 11 |
| Pages | 1217662-1217662 |
| Publication date | 2023-08-03 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2023.1217662 |
| PMID | 37601204 |
| OpenAlex | W4385550231 |
| Language | EN |
| References cited | 16 |
Objective: We report the effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11. Case report: A 45 years-old Chinese woman presented with an abnormally low HbA1c level of 3.7% (3.9%-6.1%) in a health examination. Fasting blood glucose was normal. Blood routine examination and serum bilirubin were in the normal range. HbA1c was determined by Tosoh HLC-723G11. There was an abnormal peak between A1c and A0 on the chromatogram. Hemoglobin electrophoresis indicated that the Hb E zone accounted for 25.1%. The β-thalassemia-related genes (mutant type) were βE M/N, and the related gene CD26 (A > G) was mutated. OGTT indicated prediabetes. Conclusion: Hb E heterozygosity may reduce HbA1c value with abnormal chromatograms, as determined by a Tosoh HLC G11 analyzer. The Tosoh HLC G11 analyzer can well identify Hb E variation. In this case, further blood glucose-related tests should be performed to avoid missed diagnoses. However, a large sample size is needed to confirm this conclusion
Allele · Diabetes mellitus · Gene · Hemoglobin · Loss of heterozygosity · Prediabetes · Type 2 diabetes · Chemistry · Diabetes, Cardiovascular Risks, and Lipoproteins · Hemoglobinopathies and Related Disorders · Medicine · Neonatal Health and Biochemistry · Biochemistry · Endocrinology · Internal Medicine
| Highly cited | No |
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