The effects of ambient particulate matter air pollution on platelets and hemostasis

Bibliographic Data

ID22086220
AuthorsSasinee Hantrakool (0000-0002-1248-9734, Chiang Mai University), Maitree Sriwichai (Chiang Mai University), Banphot Shaengkhamnang (Chiang Mai University), Nipapan Leetrakool (Chiang Mai University), Piangrawee Niprapan (0000-0002-5195-9188, Chiang Mai University), Sawaeng Kawichai (0000-0003-1488-5105, Chiang Mai University), Sitapak Wannakul (Chiang Mai University), Noppamas Panyasit (Chiang Mai University), Pakinee Tuntivate (Chiang Mai University), Ornkamon Wongtagan (Chiang Mai University), Rungrote Natesirinilkul (0000-0002-9840-3443, Chiang Mai University), Pimpisid Koonyosying (0000-0002-6119-7009, Chiang Mai University), Phichayut Phinyo (0000-0002-8543-6254, Chiang Mai University), Teerachat Punnachet (0000-0001-5308-6264, Chiang Mai University), Nonthakorn Hantrakun (0000-0002-6463-9992, Chiang Mai University, corresponding author), Pokpong Piriyakhuntorn (0000-0001-9730-8260, Chiang Mai University), Thanawat Rattanathammethee (0000-0003-2731-4889, Chiang Mai University), Chatree Chai‐Adisaksopha (0000-0001-7209-9722, Chiang Mai University), Chatree Chai-Adisaksopha, Ekarat Rattarittamrong (0000-0002-7819-5544, Chiang Mai University), Adisak Tantiworawit (0000-0002-2381-9292, Chiang Mai University), Lalita Norasetthada (0000-0002-2223-5711, Chiang Mai University), Somdet Srichairatanakool (0000-0002-5706-8781, Chiang Mai University)
Year2024
Volume12
Pages1410406-1410406
Publication date2024-07-18
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2024.1410406
PMID39091522
OpenAlexW4400776866
LanguageEN
References cited69

Introduction: Elevated ambient pollution exposure is potentially linked to thromboembolism. However, the mechanisms by which particulate matter (PM) interferes with the balance of hemostatic system remain unclear. This study investigates PM-mediated hemostatic changes in individuals across unique seasonal variations of ambient pollution. Methods: This prospective study was conducted between February and July 2020 during alterations in ambient pollution in Chiang Mai, Thailand. Blood tests from 30 healthy subjects were assessed at four-week intervals, four times in total. Various coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor (vWF), platelet count, and platelet functions, were evaluated. A mixed-effects model was used to analyze the impact of high PM2.5 and PM10 on hemostatic parameters. Results: Thirty male subjects with mean age of 38.9 ± 8.2 years, were included. High levels of PM2.5 and PM10 were significantly associated with PT shortening, with no such effect observed in aPTT. PM2.5 and PM10 values also positively correlated with vWF function, while vWF antigen levels remained unchanged. Soluble P-selectin showed a strong positive association with PM2.5 and PM10 levels. Platelet function analysis revealed no correlation with PM values. Conclusion: Short-term exposure to elevated PM2.5 and PM10 concentrations was linked to shortened PT and enhanced vWF function in healthy individuals. Exploring the impact of these changes on clinically relevant thrombosis is crucial. Additional studies on the pathogenesis of pollution-related thrombosis are warranted for maintaining good health

Coagulation · Fibrinogen · Hemostasis · Partial thromboplastin time · Platelet · Platelet activation · Prothrombin time · Thrombosis · Von Willebrand factor · Air Quality and Health Impacts · COVID-19 impact on air quality · Medicine · Venous Thromboembolism Diagnosis and Management · Immunology · Internal Medicine

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