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Group-based trajectory and predictors of anxiety and depression among Chinese breast cancer patients

Bibliographic Data

ID22086359
AuthorsWengao Li (Guangdong 999 Brain Hospital), Qiongxiao Zhang (Guangzhou First People's Hospital), Yining Xu (0000-0002-8357-9710, Guangzhou First People's Hospital), Hengwen Sun (Guangdong Academy of Medical Sciences), Youlu Wen (Guangdong 999 Brain Hospital), Wenjing Xu (0000-0003-4674-5262, Guangdong Academy of Medical Sciences), Yiling Tong, Tong Yiling (Guangdong Academy of Medical Sciences), Samradhvi Garg (University of Edinburgh), Yu Chen (0000-0002-0557-4316, Southern Medical University, corresponding author), Yuan Yang (0000-0002-3030-5476, Guangdong Academy of Medical Sciences, corresponding author)
Year2022
Volume10
Pages1002341-1002341
Publication date2022-10-10
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2022.1002341
PMID36299758
OpenAlexW4303969397
LanguageEN
Citations received2
References cited37

Background: The aim of the current study is to investigate the change in anxiety and depression amongst Chinese breast cancer patients and to identify causal associations between baseline variables and the trajectory of anxiety and depression within this identified group. Methods: This is a longitudinal prospective study. Three hundred women with breast cancer were recruited. Patient's depression and anxiety were repeatedly measured by PHQ-9 and GAD-7 at baseline, 6, 12, and 18 months after discharge. The SAS 9.4 PROC Traj procedure was used to examine the group-based trajectory of these recruited patients. Linear mixed models (LMM) were utilized to examine anxiety/depression changes over time, accounting for relevant baseline demographic and clinical factors. Results: About 26.3% of the participants reported none or very mild anxiety over time, 60.7% reported stable low-level anxiety, and the remaining 13.0% showed significantly decreasing trend in GAD total scores. Meanwhile, 10.7% of the participants reported none or very mild depressive symptoms over time, 66.0% reported stable PHQ total scores throughout the research period, and 23.3% were classified as the "high level-decreasing group". Patients reported significantly higher anxiety and depression scores in the first three assessments. Participants with no or mild life stress along with a positive personality tended to report lower anxiety and depression scores over time. Conclusion: Most of the breast cancer patients reported stable low-level anxiety and depression 18 months after discharge. Early assessment of optimism and stress levels among cancer patients might help identify people at risk of experiencing long-term anxiety and depression

Anxiety · Breast cancer · Cancer · Longitudinal study · Optimism · Prospective cohort study · Psychiatry · Cancer survivorship and care · Cancer-related cognitive impairment studies · Cancer, Stress, Anesthesia, and Immune Response · Clinical Psychology · Medicine · Psychology · Internal Medicine

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Citations per year2
Citation span2025 - 2025 (1)
Highly citedNo

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