The relationship between education attainment and gout, and the mediating role of modifiable risk factors

A Mendelian randomization study

Bibliographic Data

ID22086408
AuthorsXin Huang (0009-0007-5355-1008, Fujian Medical University), Xin Chen (0000-0001-7221-0056, Fujian Medical University), Qixi Liu (Fujian Medical University), Zhiwei Zhang (0000-0002-0891-0389, Fujian Medical University), Juan Miao (Fujian Medical University), Yuchan Lai (Fujian Medical University), Jinqing Wu (0000-0001-5870-3188, Fujian Medical University, corresponding author)
Year2024
Volume11
Pages1269426-1269426
Publication date2024-01-08
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2023.1269426
PMID38259784
OpenAlexW4390665826
LanguageEN
References cited58

Objective: To investigate the causal relationship between educational attainment (EA) and gout, as well as the potential mediating effects of individual physical status (IPS) such as body mass index (BMI) and systolic blood pressure (SBP) and lifestyle habits (LH) including alcohol intake frequency (drinking), current tobacco smoking (smoking), and time spent watching television (TV). Methods: Utilizing two-sample Mendelian randomization (MR), we analyzed the causal effects of EA on gout risk, and of IPS (BMI and SBP) and LH (smoking, drinking, and TV time) on gout risk. Multivariable MR (MVMR) was employed to explore and quantify the mediating effects of IPS and LH on the causal relationship between EA and gout risk. Results: = 0.020). We did not observe a causal relationship between smoking and gout, but BMI, SBP, drinking, and TV time were found to be causal risk factors for gout. Moreover, BMI, SBP, drinking, and TV time acted as mediating factors in the causal relationship between EA and gout risk, explaining 27.17, 14.83, 51.33, and 1.10% of the causal effects, respectively. Conclusion: Our study indicates that having a genetically predicted higher level of EA may provide protection against gout. We found that this relationship is influenced by IPS factors such as BMI and SBP, as well as LH including drinking and TV time

Biology · Clinical trial · Educational attainment · Environmental health · Gene · Genetic variants · Genotype · Gout · Mendelian inheritance · Mendelian randomization · Physical therapy · Randomization · Gout, Hyperuricemia, Uric Acid · Medicine · Sodium Intake and Health · Thyroid Disorders and Treatments · Genetics · Gerontology · Internal Medicine

Tools

Open DOIOpen Access