Association between metabolically healthy obesity and kidney stones

Results from the 2011–2018 National Health and Nutrition Examination Survey

Bibliographic Data

ID22087294
AuthorsWeinan Chen (0000-0003-0227-4454, Peking University), Sailimai Man (0000-0003-3032-4113, Peking University), Yang Hong (0000-0001-8720-242X, Peking University), Gaohaer Kadeerhan (0000-0002-3134-352X, Chinese Academy of Medical Sciences & Peking Union Medical College), Liang Chen (0000-0003-1553-2846, Peking University), Qingquan Xu (Peking University), Liulin Xiong, Liu‐Lin Xiong (0000-0002-1623-5969, Peking University), Tao Xu (0000-0002-0501-6445, Peking University), Bo Wang (0000-0002-0290-2134, Peking University, corresponding author), Xiaobo Huang (0000-0002-4692-1433, Peking University, corresponding author)
Year2023
Volume11
Pages1103393-1103393
Publication date2023-05-25
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2023.1103393
PMID37304121
OpenAlexW4378232802
LanguageEN
Citations received1
References cited30

Introduction The risk of kidney stones in metabolically healthy obesity (MHO) individuals is largely unexplored. This study using percent body fat (%BF) to categorize obesity, to investigate the association between MHO as well as other metabolic syndrome-obesity combined phenotypes and kidney stones in a national representative population. Materials and methods This cross-sectional study included 4,287 participants in the National Health and Nutrition Examination Survey from 2011 to 2018. Metabolically healthy status was defined as not having any component of metabolic syndrome or insulin resistance. Obesity was identified by %BF, which was measured and assessed by dual-energy x-ray absorptiometry (DXA) scan. Participants were cross-classified by metabolic health and obesity status. The outcome was self-report kidney stones. Multivariable logistic regression model was used to examine the association between MHO and kidney stones. Results A total of 358 participants had kidney stones [weighted prevalence (SE): 8.61% (0.56%)]. The weighted prevalence (SE) of kidney stones in MHN, MHOW, and MHO groups was 3.13% (1.10%), 4.97% (1.36%), and 8.55% (2.09%), respectively. After adjusting for age, sex, race and ethnicity, education level, smoking status, alcohol consumption, physical activity, daily water intake, CKD stage 3–5, and hyperuricemia, MHO individuals (OR: 2.90, 95% CI: 1.18, 7.0) had a significantly higher risk of kidney stones than those with metabolically healthy normal weight. In metabolically healthy participants, a 5% increment in %BF was associated with a significantly higher risk of kidney stones (OR: 1.60, 95% CI: 1.20, 2.14). Furthermore, a nonlinear dose–response relationship between %BF and the kidney stones was observed in metabolically healthy participants ( P for non-linearity = 0.046). Conclusion Using %BF to define obesity, MHO phenotype was significantly associated with higher risks of kidney stones, suggesting that obesity can independently contribute to kidney stones in the absence of metabolic abnormalities and insulin resistance. Regarding kidney stones prevention, MHO individuals might still benefit from lifestyle interventions aimed at healthy body composition maintenance

Body mass index · Diabetes mellitus · Environmental health · Hyperuricemia · Kidney stones · Logistic regression · Metabolic syndrome · National Health and Nutrition Examination Survey · Obesity · Population · Uric acid · Chronic Kidney Disease and Diabetes · Kidney Stones and Urolithiasis Treatments · Medicine · Paleopathology and ancient diseases · Endocrinology · Internal Medicine

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