Drug-related problems and their determinants among stroke patients in suburban China
A PCNE-based analysis with targeted initiatives
Bibliographic Data
| ID | 22087574 |
|---|---|
| Authors | Ying Liu (0000-0001-5584-7805, Beijing YouAn Hospital), Mingfen Wu (0000-0002-2761-2299, Capital Medical University), Jing Zhao (0009-0008-1906-5396, Beijing YouAn Hospital), Wenhua Yang (Beijing YouAn Hospital), Qi Wu (0000-0001-5487-3278, Department of Pharmacy, Beijing Huairou Hospital, Capital Medical University Huairou Teaching Hospital), Li Li (0000-0001-9700-9682, Beijing YouAn Hospital), Li He (0000-0002-4720-8269, Beijing YouAn Hospital), Sijie Zhang (Beijing YouAn Hospital), Fengzhao Han (Beijing YouAn Hospital, corresponding author) |
| Year | 2026 |
| Volume | 14 |
| Pages | 1771680-1771680 |
| Publication date | 2026-02-20 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2026.1771680 |
| PMID | 41799458 |
| OpenAlex | W7130663107 |
| Language | EN |
| References cited | 26 |
Background: Stroke remains a major public health burden in China, and the complexity of long-term pharmacotherapy often places stroke survivors at high risk for drug-related problems (DRPs). This study aimed to identify determinants of DRPs among community-dwelling stroke patients in suburban Beijing and to propose targeted initiatives for improving rational drug use. Methods: A cross-sectional study was conducted from August 2022 to December 2024 among 481 stroke patients. Pharmacists performed face-to-face interviews to collect demographic, clinical, and drug-related information. DRPs were identified and categorized using the Pharmaceutical Care Network Europe (PCNE) Classification System (V9.1). Chi-square tests and multivariate logistic regression were used to determine factors associated with DRPs. Results: A total of 482 DRPs were identified, corresponding to 575 cause entries. The most common problems involved suboptimal treatment effectiveness and issues requiring further clarification. Patient-related causes were predominant, especially intentional underuse or non-use of drug and inappropriate timing or dosing intervals. Logistic regression showed that alcohol consumption (OR = 1.770), comorbid diabetes (OR = 1.818), depression/anxiety symptoms (OR = 1.733), and higher animal fat intake (OR = 1.711) significantly increased DRP risk. Lower income, polypharmacy, and poorer self-rated health were also associated with DRPs. Conclusion: DRPs were highly prevalent among community-dwelling stroke survivors, driven largely by modifiable behavioral and drug-use factors. Integrating PCNE-based DRP identification with pharmacist-led community interventions may help optimize drug management, enhance treatment safety and effectiveness, and support long-term secondary prevention
Diabetes mellitus · Logistic regression · Multivariate analysis · Pharmacotherapy · Psychological intervention · Public health · Acute Ischemic Stroke Management · Antiplatelet Therapy and Cardiovascular Diseases · Stroke Rehabilitation and Recovery · Pharmacy
Determinants influencing health-promoting behaviors in individuals at high risks of stroke
Impact of Polypharmacy, Drug-Related Problems, and Potentially Inappropriate Medications in Geriatric Patients and Its Implications for Bulgaria—Narrative Review and Meta-Analysis
Evaluation of potentially inappropriate medication in older patients with cardiovascular diseases—STOPP/START-based study
Factors influencing the health behaviors of patients with ischemic stroke from a social-ecological perspective
| Highly cited | No |
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