Age-Related Sex Disparities in Esophageal Cancer Survival
A Population-Based Study in the United States
Bibliographic Data
| ID | 22089244 |
|---|---|
| Authors | Zhen-Fei Xiang, Zhenfei Xiang (Ningbo University), Huacai Xiong (Ningbo University), Hua-Cai Xiong, Danfei Hu (0000-0001-6228-692X, Ningbo University), Dan-Fei Hu, Mingyao Li (0000-0002-6547-5002, Ningbo University), Ming-Yao Li, Zhan-Chun Zhang, Zhanchun Zhang (Ningbo University), Zheng-Chun Mao, Zhengchun Mao (Ningbo University, corresponding author), Er-Dong Shen, Erdong Shen (0000-0002-6949-6740, Shanghai University of Traditional Chinese Medicine, corresponding author) |
| Year | 2022 |
| Volume | 10 |
| Pages | 836914-836914 |
| Publication date | 2022-07-12 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.836914 |
| PMID | 35903385 |
| OpenAlex | W4285027564 |
| Language | EN |
| References cited | 25 |
Background: The association between sex and the survival of patients with esophageal cancer (EC) remains controversial. We sought to systematically investigate sex-based disparities in EC survival using the Surveillance, Epidemiology, and End Results (SEER) registry data from the United States. Methods: Patients with EC diagnosed from 2004 to 2015 registered in the SEER database were selected. The association between sex and cancer-specific survival (CSS) was evaluated using survival analysis. The Inverse Probability Weighting (IPW) approach was applied to reduce the observed bias between males and females. Subgroup analyses were used to investigate the robustness of the sex-based disparity and to explore potential interaction effects with other variables. Results: < 0.001). Similar results were obtained after adjusting for selection bias using the IPW approach and multivariate regression. Subgroup analyses confirmed the relative robustness of sex as a prognostic factor. However, significant interactions were observed between sex and other variables, such as age, race, tumor grade, histology, and treatment modality. In particular, there was no survival advantage for premenopausal females compared to their male counterparts, but the association between sex and EC survival was prominent in 46-55-year-old patients. Conclusions: Female EC patients had better long-term survival than males. The association between sex and EC survival vary according to age, race, tumor grade, histology, and treatment modality. Sex-based disparity in EC-specific survival was age-related in the United States population
Cancer registry · Confounding · Inverse probability weighting · Population · Propensity score matching · Proportional hazards model · Relative survival · Surveillance, Epidemiology, and End Results · Survival analysis · Demography · Esophageal Cancer Research and Treatment · Gastroesophageal reflux and treatments · Global Cancer Incidence and Screening · Medicine · Epidemiology · Internal Medicine · Oncology
| Citation velocity | historical |
|---|---|
| Highly cited | No |