Associations between blood manganese levels and sarcopenia in adults
Insights from the National Health and Nutrition Examination Survey
Bibliographic Data
| ID | 22089366 |
|---|---|
| Authors | Bing Xu (0000-0002-0235-6057, Wenzhou Hospital of Traditional Chinese Medicine), Zuo-Xi Chen (Wenzhou Hospital of Traditional Chinese Medicine), Wu-jie Zhou (Wenzhou Hospital of Traditional Chinese Medicine), Jia Su (0000-0002-2123-9753, Wenzhou Hospital of Traditional Chinese Medicine), Qiang Zhou (0000-0002-0329-5962, Wenzhou Hospital of Traditional Chinese Medicine, corresponding author) |
| Year | 2024 |
| Volume | 12 |
| Pages | 1351479-1351479 |
| Publication date | 2024-05-13 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1351479 |
| PMID | 38803810 |
| OpenAlex | W4396867543 |
| Language | EN |
| Citations received | 1 |
| References cited | 36 |
Background: While increasing concerns arise about the health effects of environmental pollutants, the relationship between blood manganese (Mn) and sarcopenia has yet to be fully explored in the general population. Objective: This study aims to investigate the association between blood manganese (Mn) levels and sarcopenia in adults. Methods: In our study, we evaluated 8,135 individuals aged 18-59 years, utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2011 to 2018. We employed generalized additive model (GAM) to discern potential non-linear relationships and utilized the two-piecewise linear regression model to probe the association between blood Mn levels and sarcopenia. Results: After adjusting for potential confounders, we identified non-linear association between blood Mn levels and sarcopenia, with an inflection point at 13.45 μg/L. The effect sizes and the confidence intervals on the left and right sides of the inflection point were 1.006 (0.996 to 1.048) and 1.082 (1.043 to 1.122), respectively. Subgroup analysis showed that the effect sizes of blood Mn on sarcopenia have significant differences in gender and different BMI groups. Conclusion: Our results showed that a reverse U-shaped curve between blood Mn levels and sarcopenia, with an identified the inflection point at blood Mn level of 13.45 μg/L
Environmental health · Manganese · National Health and Nutrition Examination Survey · Population · Sarcopenia · Chemistry · Heavy Metal Exposure and Toxicity · Heavy Metals in Plants · Magnesium in Health and Disease · Medicine · Gerontology · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2025 - 2025 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |