Cross-sectional associations of self-perceived stress and hair cortisol with metabolic outcomes and microvascular complications in type 2 diabetes
Bibliographic Data
| ID | 22089508 |
|---|---|
| Authors | Magdalena Buckert (0000-0002-6126-0442, Heidelberg University, corresponding author), Carmen Streibel (0000-0002-4781-3418, Heidelberg University), Mechthild Hartmann (0000-0002-9329-1104, Heidelberg University), Nelly Monzer (0000-0001-9104-8947, Heidelberg University), Stefan Kopf (0000-0002-6455-3769, Heidelberg University), Julia Szendrödi (Heidelberg University), Beate Wild (0000-0002-2279-8135, Heidelberg University, corresponding author) |
| Year | 2024 |
| Volume | 12 |
| Pages | 1289689-1289689 |
| Publication date | 2024-05-15 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1289689 |
| PMID | 38813430 |
| OpenAlex | W4396937088 |
| Language | EN |
| References cited | 43 |
Introduction Increasing evidence supports chronic psychological stress as a risk factor for the development of type 2 diabetes. Much less is known, however, about the role of chronic stress in established diabetes. Methods The aim of the current study was to comprehensively assess chronic stress in a sample of 73 patients with type 2 diabetes and 48 non-diabetic control participants, and to investigate associations with indicators of glycemic control (HbA1c), insulin resistance (HOMA-IR), β-cell functioning (C-peptide), illness duration, and the presence of microvascular complications. Chronic stress was measured using questionnaires [the Perceived Stress Scale (PSS), the Screening Scale of the Trier Inventory of Chronic Stress (SSCS), the Perceived Health Questionnaire (PHQ) as well as the Questionnaire on Stress in Patients with Diabetes—Revised (QSD-R)]; hair cortisol was used as a biological indicator. Results We found that patients with type 2 diabetes had higher levels of hair cortisol in comparison to the control group ( F (1,112) = 5.3; p = 0.023). Within the diabetic group, higher hair cortisol was associated with a longer duration of the illness ( r = 0.25, p = 0.04). General perceived stress did not show significant associations with metabolic outcomes in type 2 diabetes patients. In contrast, higher diabetes-related distress, as measured with the QSD-R, was associated with lower glycemic control ( r = 0.28, p = 0.02), higher insulin resistance ( r = 0.26, p = 0.03) and a longer duration of the illness ( r = 0.30, p = 0.01). Discussion Our results corroborate the importance of chronic psychological stress in type 2 diabetes. It appears, however, that once type 2 diabetes has developed, diabetes-specific distress gains in importance over general subjective stress. On a biological level, increased cortisol production could be linked to the course of the illness
Cross-sectional study · Diabetes mellitus · Pathology · Type 2 diabetes · Diabetes Management and Education · Medicine · Stress Responses and Cortisol · Tryptophan and brain disorders · Endocrinology · Internal Medicine
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Stress-related and basic determinants of hair cortisol in humans
Associations of Childhood Neglect With the ACTH and Plasma Cortisol Stress Response in Patients With Type 2 Diabetes
A Global Measure of Perceived Stress
| Highly cited | No |
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