Air pollutants and primary liver cancer mortality

A cohort study in crop-burning activities and forest fires area

Bibliographic Data

ID22090765
AuthorsNatthapat Thongsak (0000-0002-8815-5191, Chiang Mai University), Taned Chitapanarux (0000-0002-9908-3680, Chiang Mai University), Anon Chotirosniramit (Chiang Mai University), Somvilai Chakrabandhu (0000-0002-9860-2098, Chiang Mai University), Patrinee Traisathit (0000-0003-2918-1928, Chiang Mai University), Nawapon Nakharutai (0000-0002-3145-713X, Chiang Mai University), Pimwarat Srikummoon (0000-0003-1247-3131, Chiang Mai University), Salinee Thumronglaohapun (0000-0001-7419-6171, Chiang Mai University), Titaporn Supasri (National Astronomical Research Institute of Thailand), Phonpat Hemwan (0000-0001-7461-4142, Chiang Mai University), Imjai Chitapanarux (0000-0002-8552-0149, Chiang Mai University, corresponding author)
Year2024
Volume12
Pages1389760-1389760
Publication date2024-09-23
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2024.1389760
PMID39381772
OpenAlexW4402729265
LanguageEN
Citations received1
References cited56

Introduction Northern Thailand experiences high levels of air pollution in the dry season due to agricultural waste burning and forest fires. Some air pollutants can enter the bloodstream, and the liver has the role of detoxifying these along with other harmful substances. In this study, we assessed the effects of long-term exposure to air pollutants on liver cancer mortality in this area. Methods A cohort of 10,859 primary liver cancer patients diagnosed between 2003 and 2018 and followed up to the end of 2020 were included in the study. Extended time-varying covariates of the annually averaged pollutant concentrations updated each year were utilized. The associations between air pollutants and mortality risk were examined by using a Cox proportional hazard model. Results Metastatic cancer stage had the highest adjusted hazard ratio (aHR) of 3.57 (95% confidence interval (CI):3.23–3.95). Being male (aHR = 1.10; 95% CI: 1.04–1.15), over 60 years old (aHR = 1.16; 95% CI: 1.11–1.21), having a history of smoking (aHR = 1.16; 95%CI: 1.11–1.22), and being exposed to a time-updated local concentration of PM 2.5 of 40 μg/m 3 (aHR = 1.10; 95% CI: 1.05–1.15) increased the mortality risk. Conclusion We found that air pollution is one of several detrimental factors on the mortality risk of liver cancer

Air pollution · Biology · Cancer · Cohort · Cohort study · Confidence interval · Environmental health · Hazard ratio · Liver cancer · Pollutant · Proportional hazards model · Air Quality and Health Impacts · Carcinogens and Genotoxicity Assessment · Environmental Science · Fire effects on ecosystems · Medicine · Ecology · Internal Medicine

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