Prevalence and risk factors of negative emotions in infertile women

A systematic review and meta-analysis

Bibliographic Data

ID22091150
AuthorsLiuxin Hu (Department of Reproductive Medicine, Jiangxi Province Hospital of Integrated Chinese and Western Medicine), Lilai Hu (Integrated Chinese Medicine (China)), Youchang Yuan (Jiangxi University of Traditional Chinese Medicine), Yanjing Li (0000-0002-6036-547X, Jiangxi University of Traditional Chinese Medicine), Mian Cai (Jiangxi University of Traditional Chinese Medicine), Jie Yin (0000-0002-2063-8437, Jiangxi University of Traditional Chinese Medicine), Li‐Juan Zhu (0000-0003-3478-1725, Integrated Chinese Medicine (China), corresponding author), Lijuan Zhu (0000-0001-5304-7222, Department of Reproductive Medicine, Jiangxi Province Hospital of Integrated Chinese and Western Medicine)
Year2025
Volume13
Pages1701381-1701381
Publication date2025-12-04
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2025.1701381
PMID41426667
OpenAlexW4416975912
LanguageEN
References cited97

Objective: The purpose of this study was to investigate the prevalence of anxiety and depression in female infertility patients, as well as the risk factors that are linked to these conditions, through a systematic review and meta-analysis. Methods: Eight databases-PubMed, Web of Science, Embase, Cochrane Library, Sinomed, CNKI, VIP, and WanFang-were thoroughly searched, with the search period lasting until February 28, 2025. Research on anxiety or depression and the risk factors linked to it that involved female infertility patients was included. Information was taken from each study, including study region, patient age, prevalence rates, and risk factors for anxiety or depression in female infertility patients. Results: It was discovered that 41% [95% CI (0.35, 0.47)] of female infertility patients had anxiety, and 42% [95% CI (0.36, 0.48)] had depression. Age [OR = 1.38, 95% CI (1.10, 1.73)], duration of infertility [OR = 1.68, 95% CI (1.30, 2.17)], treatment expenses [OR = 2.04, 95% CI (1.78, 2.34)], and lack of knowledge about Assisted Reproductive Technology (ART)-related Information [OR = 1.70, 95% CI (1.26, 2.29)] were significantly associated with anxiety. Age [OR = 1.16, 95% CI (1.00, 1.33)], duration of infertility [OR = 1.83, 95% CI (1.56, 2.16)], treatment expenses [OR = 1.47, 95% CI (1.25, 1.74)], history of miscarriage [OR = 2.17, 95% CI (1.43, 3.31)], and primary infertility [OR = 2.15, 95% CI (1.55, 3.00)] were risk factors for depression. Other factors analyzed, such as place of residence, no reproductive history, and family income, were not found to be statistically significant. Conclusion: Women with infertility face a high incidence of anxiety and depression, which is related to factors such as treatment costs, age, and duration of infertility. A history of miscarriage or primary infertility further increases the risk of depression, while a lack of knowledge of assisted reproductive technologies increases the risk of anxiety. Systematic review registration: PROSPERO, https://www.crd.york.ac.uk/PROSPERO/view/CRD420251036068

Infertility · MEDLINE · Public health · Risk factor · Family Dynamics and Relationships · Ovarian function and disorders · Reproductive Health and Technologies · Epidemiology

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