Higher Fibroblast Growth Factor 23 Levels Are Causally Associated With Lower Bone Mineral Density of Heel and Femoral Neck
Evidence From Two-Sample Mendelian Randomization Analysis
Bibliographic Data
| ID | 22091508 |
|---|---|
| Authors | Yue Wang (0000-0001-8527-9175, Shanghai Jiao Tong University), Hui Wang (0000-0001-5109-8691, Shanghai Jiao Tong University, corresponding author), Peizhan Chen (0000-0003-0279-4759, Ruijin Hospital, corresponding author) |
| Year | 2020 |
| Volume | 8 |
| Pages | 467-467 |
| Publication date | 2020-09-02 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2020.00467 |
| PMID | 32984251 |
| OpenAlex | W3081575924 |
| Language | EN |
| Citations received | 1 |
| References cited | 53 |
Background: Previous observational studies have indicated that high levels of fibroblast growth factor 23 (FGF23), a phosphoric hormone that inhibits calcitriol synthesis, in the blood is associated with the reduced bone mineral density (BMD); however, whether this association is causal remains unclear. In this study, we conducted a Mendelian Random (MR) study to investigate whether the genetic predisposition of higher FGF23 levels was causally associated with lower BMD in adults. Methods: A two-sample MR was performed with five single nucleotide polymorphisms significantly associated with FGF23, selected as instrumental variables. Two-sample MR estimates were derived from summary-level data of large-sample genome-wide association studies for BMD and the levels of bone metabolism characteristics. Results: The two-sample MR analysis showed that for every 1-unit increase in the log-transformed blood FGF23 level (pg/mL), the decreased levels of adult heel BMD (β = -0.201, se = 0.084, P = 0.016) and femoral neck BMD (β = -0.286, se = 0.126, P = 0.022) were noted, indicative of a causal relationship based on the inverse variance weighting method. However, FGF23 levels were not correlated with adult lumbar spine BMD (β = -0.166, se = 0.193, P = 0.389), and forearm BMD (β = -0.186, se = 0.366, P = 0.610). Moreover, the two-sample MR analysis suggested that there was no evidence for associations between FGF23 and adult calcium, phosphorus, 25(OH)D, creatinine, and magnesium levels. Conclusions: This study suggests that there may be a causal relationship between blood FGF23 levels and BMD of the heel and femoral neck in adults; however, more investigations are necessary to determine whether FGF23 may be a potential biomarker and/or therapeutic target for diseases that affect bone mineralization
Biology · Bone mineral · Calcium · Femoral neck · Fibroblast growth factor 23 · Genotype · Heel · Mendelian randomization · Osteoporosis · Parathyroid hormone · Fibroblast Growth Factor Research · Genetic Syndromes and Imprinting · Medicine · Parathyroid Disorders and Treatments · Anatomy · Endocrinology · Genetics · Internal Medicine · Physiology
| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |