Effect of Hibiscus sabdariffa Calices on Dyslipidemia in Obese Adolescents
A Triple-masked Randomized Controlled Trial
Bibliographic Data
| ID | 22320215 |
|---|---|
| Authors | Ali Sabzghabaee, Ali Mohammad Sabzghabaee (0000-0001-8115-4615), Ehsan Ataei (Isfahan University of Medical Sciences, corresponding author), Roya Kelishadi (0000-0001-7455-1495, Isfahan University of Medical Sciences), Alireza Ghannadi (0000-0003-3048-925X, Isfahan University of Medical Sciences), Rasool Soltani (0000-0001-9301-4732, Isfahan University of Medical Sciences), Shirinsadat Badri (0000-0002-6851-9090, Isfahan University of Medical Sciences), Shahin Shirani (0000-0002-0393-4234, Isfahan University of Medical Sciences) |
| Year | 2013 |
| Volume | 25 |
| Issue | 2 |
| Pages | 76 |
| Publication date | 2013-01-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Materia Socio Medica (JOURNAL) |
| Journal identifiers | ISSN: 1512-7680 • E-ISSN: 1986-597X |
| Publisher | ScopeMed (PUBLISHER • TR) |
| DOI | 10.5455/msm.2013.25.76-79 |
| PMID | 24082826 |
| OpenAlex | W2121241675 |
| Language | EN |
| Citations received | 1 |
| References cited | 4 |
CONFLICT OF INTEREST: none declared. OBJECTIVE: We aimed to evaluate the effects of Hibiscus sabdariffa (HS) calices on controlling dyslipidemia in obese adolescents. METHODOLOGY: In this triple blind randomized placebo-controlled clinical trial which was registered in the Iranian registry for clinical trials (IRCT201109122306N2), 90 obese adolescents aged 12-18 years with documented dyslipidemia were randomly assigned in two groups of cases who received 2 grams of fine powdered calices of Hibiscus sabdariffa per day for one month and controls who received placebo powder with the same dietary and physical activity recommendations and duration of exposure. Full lipid profile and fasting blood sugar measured before and after the trial. Data were analyzed using multivariate general linear model. FINDINGS: Overall, 72 participants (mean age of 14.21±1.6, 35 boys) completed the trial. The two arms of the study (cases and controls) were not statistically different in terms of age, gender, weight, body mass index (BMI) and lipid profile before the trial. Serum total cholesterol, low density lipoprotein cholesterol and serum triglyceride showed a significant decrease in cases group but high density lipoprotein cholesterol level was not changed significantly. CONCLUSION: It is concluded that Hibiscus sabdariffa calyces powder may have significant positive effects on lipid profile of adolescents which maybe attributed to its polyphenolic and antioxidant content. Further studies are needed on dose-response and formulation optimization
Body mass index · Cholesterol · Dyslipidemia · Hibiscus sabdariffa · Lipid Profile · Obesity · Placebo · Randomized controlled trial · Traditional medicine · Triglyceride · Hibiscus Plant Research Studies · Medicine · Natural Products and Biological Research · Polysaccharides Composition and Applications · Gastroenterology · Internal Medicine
| Citations per year | 0.08 |
|---|---|
| Citation span | 2013 - 2013 (1) |
| Highly cited | No |