Elevated Serum Leptin Level Is Associated with Body Mass Index But Not with Serum C-reactive Protein and Erythrocyte Sedimentation Rate Values in Hemodialysis Patients
Bibliographic Data
| ID | 22320506 |
|---|---|
| Authors | Amela Dervisevic (0000-0002-4251-1437, University of Sarajevo), Anela Subo (0000-0003-3867-2542, Institute of Metrology of Bosnia and Herzegovina), Nesina Avdagic (0000-0003-4089-3037, University of Sarajevo), Asija Zaciragic (0000-0002-3293-4698, University of Sarajevo), Nermina Babic (University of Sarajevo), Almir Fajkic (0000-0002-1985-9355, University of Sarajevo), Orhan Lepara (University of Sarajevo), Almira Hadžović-Džuvo (0000-0003-2750-2206, University of Sarajevo), Almira HadzovicDzuvo |
| Year | 2015 |
| Volume | 27 |
| Issue | 2 |
| Pages | 99 |
| Publication date | 2015-01-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Materia Socio Medica (JOURNAL) |
| Journal identifiers | ISSN: 1512-7680 • E-ISSN: 1986-597X |
| Publisher | ScopeMed (PUBLISHER • TR) |
| DOI | 10.5455/msm.2015.27.99-103 |
| PMID | 26005385 |
| OpenAlex | W2094927075 |
| Language | EN |
OBJECTIVES: Aim of the present study was to investigate serum concentration of leptin and its association with values of body mass index (BMI), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) in hemodialysis (HD) patients. METHODS: This cross-sectional study included 60 HD patients (34 male, 26 female) and 30 age- and sex-matched (4 males, 26 females) apparently healthy subjects. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA). Serum CRP concentration was measured by means of particle-enhanced immunonephelometry. ESR value was determined by Western Green method. BMI was calculated as weight (kg) divided by height squared (m(2)). RESULTS: Results have shown that median serum leptin concentration (30.65 ng/mL; 12.48-86.40 ng/mL) was statistically significantly higher in HD patients compared to median serum leptin concentration (15.75 ng/mL; 9.15-30.65 ng/mL) in the control group of healthy subjects (p 0.05). Negative correlation between ESR values and serum leptin concentrations in HD patients was determined but it was not statistically significant (rho= -0.029; p>0.05). CONCLUSIONS: Increased serum concentration of leptin as pro-inflammatory cytokine as well as elevated serum values of CRP and ESR indicate presence of systemic micro inflammation in HD patients. Results of the present study point to possible use of serum leptin concentration as an indicator of nutritional status in HD patients based on observed significant positive correlation between serum leptin concentrations and BMI values. However, absence of significant association between serum leptin and CRP levels as well as between serum leptin concentrations and ESR values in HD patients requires further investigation and clarification
Body mass index · C-reactive protein · Erythrocyte sedimentation rate · Hemodialysis · Inflammation · Leptin · Obesity · Adipokines, Inflammation, and Metabolic Diseases · Chemistry · Genetic Syndromes and Imprinting · Medicine · Regulation of Appetite and Obesity · Endocrinology · Gastroenterology · Internal Medicine
| Highly cited | No |
|---|