The Evaluation of Intestinal Permeability in Preeclamptic Pregnancy

Background: Zonulin is a physiological protein that regulates the tight connections and permeability of the intestine, serving as a biomarker for impaired intestinal permeability. Objective: The aim of this study was to examine zonulin levels in preeclampsia, to investigate its associations with the cellular immune response marker soluble interleukin-2 receptor (sIL-2R) and exogenous antigen load marker lipopolysaccharide binding protein (LBP) and to evaluate the implications of these findings in the etiopathogenesis of preeclampsia. Methods: We designed a cross-sectional case-control study and enrolled 22 pregnant women with preeclampsia and 22 healthy pregnant controls. Plasma zonulin levels were determined by ELISA. Serum sIL-2R and LBP levels were assessed by chemiluminescent immunometric methods. Results: Women with preeclampsia had lower levels of plasma zonulin and serum LBP than normotensive healthy controls (p

Biology · Biomarker · Case-control study · Immune system · Intestinal Permeability · Lipopolysaccharide · Preeclampsia · Pregnancy · Medicine · Pregnancy and preeclampsia studies · Reproductive System and Pregnancy · Sodium Intake and Health · Endocrinology · Immunology · Internal Medicine