Blood-Stream Infections
Causative Agents, Antibiotic Resistance and Associated Factors in Older Patients
Bibliographic Data
| ID | 22320838 |
|---|---|
| Authors | Hoang Quang, Hoang-Van Quang (Trường ĐH Nguyễn Tất Thành), Le Nhung, Le-Thi Kim Nhung (Trường ĐH Nguyễn Tất Thành), Pham Thuy, Pham-Thi Thanh Thuy (Hung Vuong Hospital), Phan Quyen, Phan Chau Quyen (Hung Vuong Hospital), Le Huy, Le Bao Huy (HCMC Hospital of Dermato Venereology), Ho Dung, Dung Si Ho (0000-0002-2687-4975, Pham Ngoc Thach University of Medicine) |
| Year | 2024 |
| Volume | 36 |
| Issue | 1 |
| Pages | 82 |
| Publication date | 2024-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Materia Socio Medica (JOURNAL) |
| Journal identifiers | ISSN: 1512-7680 • E-ISSN: 1986-597X |
| Publisher | ScopeMed (PUBLISHER • TR) |
| DOI | 10.5455/msm.2024.36.82-89 |
| PMID | 38590604 |
| OpenAlex | W4393285078 |
| Language | EN |
| References cited | 3 |
Background: The rate of multi-drug antibiotic resistance in nosocomial bloodstream infections in elderly patients is increasing. This study examined the data for bloodstream infections to gain a better understanding of bacterial antibiotic resistance. Methods: This was a retrospective study of 817 patients with the first positive blood culture between January 1, 2016 and December 31, 2019. Results: Moyen’s age was 77.4 ± 9.8 years, male (52.4%) and SOFA 5.0 ± 4. ESBL(+) rate was 78/817 (9.5%). ESBL(+) rate for Escherichia coli and Klebsiella pneumoniae was 69/141 (48.9%) and 9/52 (17.3%), respectively. The most common isolates were Escherichia coli (17.3%), Stenotrophomonas maltophilia (13.7%), and Staphylococcus species (23.1%). The rate of septic shock and mortality accounted for 22.3% and 28.9%, respectively. Escherichia coli is highly sensitive to carbapenem, and resistant (>50%) with quinolone and aminoside. Klebsiella pneumoniae and Pseudomonas aeruginosa were highly sensitive to carbapenem. Acinetobacter baumannii was resistant to meropenem (75%). Stenotrophomonas maltophilia was sensitive to quinolone (13.8 %), and highly resistant to remaining antibiotics. Methicillin-resistant Staphylococcus aureus had a low resistance rate for vancomycin, teicoplanin, and linezolid. Multivariate analysis showed that the significant factors associated with mortality were age >75; SOFA >7; respiratory infection; intensive care unit treatment and presentation with septic shock. Conclusion: The mortality rate was still high, especially for antibiotic-resistant agents
Acinetobacter baumannii · Antibiotic resistance · Antibiotics · Bacteria · Biology · Drug resistance · Escherichia coli · Klebsiella pneumoniae · Linezolid · Meropenem · Mortality rate · Pseudomonas aeruginosa · Sepsis · Septic shock · Staphylococcus aureus · Stenotrophomonas maltophilia · Teicoplanin · Vancomycin · Antibiotic Resistance in Bacteria · Bacterial Identification and Susceptibility Testing · Infections and bacterial resistance · Medicine · Internal Medicine · Microbiology
| Citation velocity | historical |
|---|---|
| Highly cited | No |