Facial clefting and Amerindian admixture in populations of Santiago, Chile
Bibliographic Data
| ID | 22474355 |
|---|---|
| Authors | Hernán M Palomino, Hernan Palomino (University of Chile), Doris Cauvi (University of Chile), Sara A Barton (0000-0001-8227-5339, The University of Texas Health Science Center at Houston), Ranajit Chakraborty (0000-0001-9576-916X, The University of Texas Health Science Center at Houston, corresponding author) |
| Year | 1997 |
| Volume | 9 |
| Issue | 2 |
| Pages | 225-232 |
| Publication date | 1997-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 1042-0533 • E-ISSN: 1520-6300 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/(sici)1520-6300(1997)9:2<225::aid-ajhb9>3.0.co;2-z |
| PMID | 28561520 |
| OpenAlex | W2066348226 |
| Language | EN |
| References cited | 14 |
Among congenital malformations, cleft lip with and/or without cleft palate has the highest relative frequencies and shows ethnic variation in prevalence. Both malformations are generally more common among the Asian than European populations. Many populations of Chile have genes of Amerindian and Spanish ancestry, with considerable variation in the degree of Amerindian admixture. Therefore, the association of clefting incidence with Amerindian admixture was investigated. The frequency of cleft lip and/or cleft palate in infants born in three private and two public maternity service clinics of Santiago, Chile, is reported. The private clinic patients have a higher socioeconomic status (SES) than those receiving the public services. They also differ in estimated Amerindian admixture. More than 200,900 consecutive birth records were reviewed. The rate of clefting malformations is 15.3 per 10,000 live births. Based on allele frequencies at the ABO and Rh blood group loci, the percentage of Amerindian admixture is higher in infants born in the public compared to those born in the private maternity service clinics. Amerindian admixture is positively correlated (Spearman's p = 0.9, P = 0.008) with clefting rate across these samples. Clefting is also associated with SES, with lower SES showing higher clefting rates. Mothers of clefting newborns also have higher estimated Amerindian admixture compared to those of normal newborns. The results support the view that in Chilean populations, susceptibility to clefting is related to Amerindian ancestry. Am. J. Hum. Biol. 9:225-232, 1997. © 1997 Wiley-Liss, Inc.
Biology · Birth records · Birth weight · Congenital malformations · Ethnic group · Hum · Incidence (geometry) · Population · Pregnancy · Socioeconomic status · Cleft Lip and Palate Research · Congenital Anomalies and Fetal Surgery · Craniofacial Disorders and Treatments · Demography · Genetics · Medicine
Distribution of hereditary blood groups among Indians in South America. IV. In Chile with inferences concerning genetic connections between Polynesia and America
Epidemiology of cleft lip and palate. An attempt to rule out chance correlations
Congenital Malformations in the American Indian
Frequencies of complex diseases in hybrid populations
Peopling of Andean South America
| Highly cited | No |
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