Impact of microbiota in colorectal carcinogenesis
Lessons from experimental models
Bibliographic Data
| ID | 23239011 |
|---|---|
| Authors | Linda Chia-Hui Yu (Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.), Petra Ewald (corresponding author), Shu-Chen Wei (Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.), Yen-Hsuan Ni (0000-0002-1158-5249, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.) |
| Year | 2018 |
| Volume | 16 |
| Issue | 3 |
| Pages | 346 |
| Publication date | 2018-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Intestinal Research (JOURNAL) |
| Journal identifiers | ISSN: 1598-9100 • E-ISSN: 2288-1956 |
| Publisher | Korean Association for the Study of Intestinal Diseases (PUBLISHER • KR) |
| DOI | 10.5217/ir.2018.16.3.346 |
| OpenAlex | W30090033 |
| Language | EN |
| Citations received | 1 |
| References cited | 115 |
A role of gut microbiota in colorectal cancer (CRC) growth was first suggested in germ-free rats almost 50 years ago, and the existence of disease-associated bacteria (termed pathobionts) had becoming increasingly evident from experimental data of fecal transplantation, and microbial gavage or monoassociation. Altered bacterial compositions in fecal and mucosal specimens were observed in CRC patients compared to healthy subjects. Microbial fluctuations were found at various cancer stages; an increase of bacterial diversity was noted in the adenoma specimens, while a reduction of bacterial richness was documented in CRC samples. The bacterial species enriched in the human cancerous tissues included Escherichia coli , Fusobacterium nucleatum , and enterotoxigenic Bacteroides fragilis . The causal relationship of gut bacteria in tumorigenesis was established by introducing particular bacterial strains in in situ mouse CRC models. Detailed experimental protocols of bacterial gavage and the advantages and caveats of different experimental models are summarized in this review. The microbial genotoxins, enterotoxins, and virulence factors implicated in the mechanisms of bacteria-driven tumorigenesis are described. In conclusion, intestinal microbiota is involved in colon tumorigenesis. Bacteria-targeting intervention would be the next challenge for CRC.
Lexicography and Language Studies · Linguistic Education and Pedagogy · Linguistic research and analysis · Philosophy
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,11 |
| Citation span | 2017 - 2017 (1) |
| Citation velocity | historical |
| Highly cited | No |