Exploring the Limits of iCS in Moderate Alzheimer's Disease
A Randomized Controlled Trial
Bibliographic Data
| ID | 23308659 |
|---|---|
| Authors | Susana I Justo‐Henriques (Instituto Politécnico de Beja), Susana I Justo-Henriques (Instituto Politécnico de Beja), Rosa C Gomes Silva (Universidade do Porto), Isabel Gómez‐Soria (0000-0002-0061-3312, Universidad de Zaragoza), Ricardo M V de São João (Instituto Politécnico de Santarém), Oscar Ribeiro (0000-0001-7396-639X, University of Aveiro) |
| Year | 2026 |
| Publication date | 2026-07-31 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Japanese Psychological Research (JOURNAL) |
| Journal identifiers | ISSN: 0021-5368 • E-ISSN: 1468-5884 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1111/jpr.70041 |
| OpenAlex | W7172044353 |
| Language | EN |
| References cited | 62 |
Alzheimer's disease (AD) involves deficits in multiple cognitive domains, particularly memory and executive function. This study explored the effectiveness of an individual cognitive stimulation program in older adults with moderate AD. A multicenter, parallel, two‐arm, single‐blind randomized controlled trial was conducted with 80 older adults. Participants were randomly assigned to either the individual cognitive stimulation group ( n = 39, 24 sessions, twice a week for 12 weeks) or the treatment‐as‐usual group ( n = 41). Cognitive outcomes—global cognition, memory, and executive function—were assessed at baseline, post‐intervention, and at 12‐week follow‐up. Analyses were conducted using linear mixed‐effects models under an intention‐to‐treat framework, complemented by repeated‐measures analysis of variance. Results showed a significant Group × Time interaction for free recall memory and for Alzheimer's Disease Assessment Scale—Cognitive Subscale “recall of test instructions,” with a marginal interaction for “comprehension of spoken language.” However, no significant between‐group differences were observed at any time point. No other significant between‐group differences over time were found using linear mixed‐effects models or repeated‐measures analysis of variance. Although some benefits were identified, the reduced responsiveness in more advanced AD stages highlights the challenges of cognitive intervention at this phase.
Affect (linguistics) · Cognition · Effects of sleep deprivation on cognitive performance · Free recall · Intervention (counseling) · Memory test · Randomized controlled trial · Recall · Test (biology) · Dementia and Cognitive Impairment Research · Neurobiology of Language and Bilingualism · Traumatic Brain Injury Research
| Citation velocity | historical |
|---|---|
| Highly cited | No |