Effects of exercise on clinical outcomes in patients undergoing haemodialysis for chronic kidney disease

An umbrella review

Bibliographic Data

ID23311653
AuthorsMeihui Huang (Central South University), Zhihao Xie (0009-0006-6883-9269, Chinese Academy of Medical Sciences & Peking Union Medical College), Bin Lin (0000-0002-4099-309X, Central South University), Wenfeng Xiao (0000-0002-4369-9371, Central South University), Xiao Wm (Central South University), Ting Wen (0000-0001-5738-2554, Central South University), Y Y Li (0000-0003-4140-504X, Central South University), Yusheng Li (0000-0003-1981-9246, Central South University), Haitao Long (Central South University), Xucheng Yang (0000-0003-0025-1996, Central South University), Kai Zhang (0000-0002-7401-2931, Central South University)
Year2026
Volume16
Pages04227-04227
Publication date2026-07-24
Open AccessYes
TypeARTICLE
VenueJournal of Global Health (JOURNAL)
Journal identifiersISSN: 2047-2978 • E-ISSN: 2047-2986
PublisherInternational Society of Global Health (PUBLISHER • GB)
DOI10.7189/jogh.16.04227
PMID42495748
OpenAlexW7170531334
LanguageEN
References cited54

Background: Exercise is increasingly recommended for haemodialysis patients with chronic kidney disease, yet the evidence from meta-analyses remains fragmented, and its methodological quality has not been systematically evaluated. Methods: We systematically searched Embase, PubMed/MEDLINE, Cochrane Library, and Web of Science up to January 2026. We evaluated the methodological quality of studies using the 'Measurement Tool to Assess Systematic Reviews 2'. We used GRADE system to rate the evidence level for each outcome as high, moderate, low, or very low. Results: peak, DBP, PCS, MCS, CRP, and depression, but not Kt/V, 6MWT, or SBP. Conclusions: Aerobic exercise may improve cardiorespiratory fitness, dialysis efficiency, inflammation, and depression; resistance may enhance muscle strength and physical function; combined training offers the broadest benefits. Individualized prescriptions are supported, but high-certainty evidence is lacking. Registration: PROSPERO: CRD420251244373.

Aerobic exercise · Anaerobic exercise · Cardiorespiratory fitness · Chronic kidney failure · Dialysis · Exercise prescription · Kidney disease · MEDLINE · Systematic review · Chronic Kidney Disease and Diabetes · Dialysis and Renal Disease Management · Parathyroid Disorders and Treatments

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