Chronic Fatigue Syndrome

A Working Case Definition

Datos Bibliográficos

ID23314489
AutoresGARY P HOLMES (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska, autor de correspondencia), JONATHAN E KAPLAN (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), NELSON M GANTZ (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), Anthony L Komaroff (0000-0001-7672-2518, Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), LAWRENCE B SCHONBERGER (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), STEPHEN E STRAUS (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), James F Jones (0000-0002-1997-4257, Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), RICHARD E DUBOIS (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), CHARLOTTE CUNNINGHAM-RUNDLES (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), Savita Pahwa (0000-0002-4470-4216, Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), GIOVANNA TOSATO (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), Leonard S Zegans (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), DAVID T PURTILO (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), NATHANIEL BROWN (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), Robert T Schooley (0000-0002-2498-8426, Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), IRENA BRUS (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska)
Año1988
Volumen108
Número3
Páginas387-389
Fecha de publicación1988-03-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaAnnals of Internal Medicine (JOURNAL)
Identificadores de la revistaISSN: 0003-4819 • E-ISSN: 1539-3704
EditorialAmerican College of Physicians (PUBLISHER • US)
DOI10.7326/0003-4819-108-3-387
PMID2829679
OpenAlexW2138995305
IdiomaEN
Citas recibidas78
Referencias citadas7

The chronic Epstein-Barr virus syndrome is a poorly defined symptom complex characterized primarily by chronic or recurrent debilitating fatigue and various combinations of other symptoms, including sore throat, lymph node pain and tenderness, headache, myalgia, and arthralgias. Although the syndrome has received recent attention, and has been diagnosed in many patients, the chronic Epstein-Barr virus syndrome has not been defined consistently. Despite the name of the syndrome, both the diagnostic value of Epstein-Barr virus serologic tests and the proposed causal relationship between Epstein-Barr virus infection and patients who have been diagnosed with the chronic Epstein-Barr virus syndrome remain doubtful. We propose a new name for the chronic Epstein-Barr virus syndrome--the chronic fatigue syndrome--that more accurately describes this symptom complex as a syndrome of unknown cause characterized primarily by chronic fatigue. We also present a working definition for the chronic fatigue syndrome designed to improve the comparability and reproducibility of clinical research and epidemiologic studies, and to provide a rational basis for evaluating patients who have chronic fatigue of undetermined cause.

Chronic fatigue · Chronic fatigue syndrome · Chronic pain · Intensive care medicine · myalgia · Physical therapy · Sore throat · Virus · Fibromyalgia and Chronic Fatigue Syndrome Research · Immunology · Medicine