Factors Affecting Adherence to Antiretroviral Therapy

Datos Bibliográficos

ID23338659
AutoresMargaret A Chesney (0000-0001-6038-3486, University of California, San Francisco, autor de correspondencia)
Año2000
Volumen30
NúmeroSupplement_2
PáginasS171-S176
Fecha de publicación2000-06-01
Peer ReviewedSí
Open AccessNo
TipoARTICLE
RevistaClinical Infectious Diseases (JOURNAL)
Identificadores de la revistaISSN: 1058-4838 • E-ISSN: 1537-6591
EditorialOxford University Press (OUP) (PUBLISHER)
DOI10.1086/313849
PMID10860902
OpenAlexW2043390279
IdiomaEN
Citas recibidas63
Referencias citadas5

In both clinical trials and clinical practice, nonadherence to medications is widespread among patients with chronic diseases. The shift to combination therapies for treating human immunodeficiency virus (HIV)-infected individuals has increased adherence challenges for both patients and health-care providers. Estimates of average rates of nonadherence to antiretroviral therapy range from 50% to 70%. Adherence rates of <80% are associated with detectable viremia in a majority of patients. The principal factors associated with nonadherence appear to be patient-related, including substance and alcohol abuse. However, other factors may also contribute, such as inconvenient dosing frequency, dietary restrictions, pill burden, and side effects; patient-health-care provider relationships; and the system of care. We discuss the major reasons reported by HIV-infected individuals for not taking their medications. Improving adherence probably requires clarifying the treatment regimen and tailoring it to patient lifestyles.

Antiretroviral therapy · Dosing · Family medicine · Health care · Human immunodeficiency virus (HIV) · Intensive care medicine · Pill · Regimen · Viral load · Viremia · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Internal Medicine · LGBTQ Health, Identity, and Policy · Medicine · Nursing