The Microbiota-Gut-Brain Axis
Bibliographic Data
The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system, involving microbial metabolites such as short-chain fatty acids, branched chain amino acids, and peptidoglycans. Many factors can influence microbiota composition in early life, including infection, mode of birth delivery, use of antibiotic medications, the nature of nutritional provision, environmental stressors, and host genetics. At the other extreme of life, microbial diversity diminishes with aging. Stress, in particular, can significantly impact the microbiota-gut-brain axis at all stages of life. Much recent work has implicated the gut microbiota in many conditions including autism, anxiety, obesity, schizophrenia, Parkinson’s disease, and Alzheimer’s disease. Animal models have been paramount in linking the regulation of fundamental neural processes, such as neurogenesis and myelination, to microbiome activation of microglia. Moreover, translational human studies are ongoing and will greatly enhance the field. Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
Autism · Bioinformatics · Biology · Disease · Gut flora · Gut–brain axis · Immune system · Microbiome · Pathology · Gastrointestinal motility and disorders · Gut microbiota and health · Immunology · Medicine · Neuroscience · Tryptophan and brain disorders
Mechanistic Mayhem
Alterações Na Microbiota Gastrointestinal De Crianças Com Transtorno Do Espectro Autista
The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes
Altered functional connectivity strength in chronic insomnia associated with gut microbiota composition and sleep efficiency
Association of depression with gastroesophageal reflux disease, and the mediating role of risk factors
Lower serum levels of IL-1β and IL-6 cytokines in adolescents with anorexia nervosa and their association with gut microbiota in a longitudinal study
Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment
The schizophrenia and gut microbiota
Phylum Firmicutes in the Faecal Microbiota Demonstrates a Direct Association with Arterial Hypertension in Individuals of the Kazakh Population Without Insulin Resistance
Exercise Interventions Improved Sleep Quality through Regulating Intestinal Microbiota Composition
Infant fecal microbiota composition and attention to emotional faces
Aqueous Polygalae Radix extract (PRE) prolongs the lifespan of C. elegans and alleviates D-galactose-induced oxidative stress in the mouse liver and brain by modulating PPARγ/Mapk
Gut Microbiota Changes in Patients With Major Depressive Disorder Treated With Vortioxetine
Intestinal metabolites and the risk of autistic spectrum disorder
Autism spectrum disorder research
Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms
Association of dietary inflammatory index and dietary oxidative balance score with gastrointestinal cancers in NHANES 2005–2018
Markers of intestinal barrier damage in patients with chronic insomnia disorder
The Role of Chronic Stress in Normal Visceroception
Gut microbiota and metabolic characteristics in subthreshold depression based on multi-omics
The Gut Microbiota and Associated Metabolites Are Altered in Sleep Disorder of Children With Autism Spectrum Disorders
Chrononutrition interventions for mental health
A taxon-centered review of bacterial shifts in psychiatric disorders
Omics approaches open new horizons in major depressive disorder
The Microbiome–Gut–Brain Axis and Dementia
Antipsychotic-Induced Weight Gain and Clinical Improvement
Association between dietary patterns and depression symptoms among adults with or without diabetes in Qatar
El mito de Edipo en la tradición culta occidental y sus interpretaciones
Nutrition as Metabolic Treatment for Anxiety
The impact of alcohol consumption on the relationship between depression and chronic diarrhea
Dementia in the Middle East and North Africa
The allure of microbiome research
A Influência Da Microbiota Intestinal No Transtorno Depressivo
Nutritional strategies supporting brain health
Gender and age disparities in attitude and preferences of probiotic and prebiotic-rich foods and supplements among adults in Saudi Arabia
Self-rated health, mental wellbeing, nutrition habits, and their association with morbidity of ischemic heart disease
Econeurobiology and brain development in children
Gut microbiota–intestinal barrier crosstalk
Association of joint trajectories of dietary diversity and physical activity with cognitive function in older adults
Intergenerational crosstalk of brain-gut axis in parental Nd2O3 exposure-induced offspring neurotoxicity and cognitive dysfunction
Annual Research Review
Domestication and microbiome
Holobiont Development
Comparative Analysis of Fecal Microbiome Composition in Zoo‐Housed Colobines
Microbiome-gut-brain axis in brain development, cognition and behavior during infancy and early childhood
Associations Between the Gut Microbiota and Internalizing Behaviors in Preschool Children
Gut Microbiota in Psychiatric Disorders
Targeting the perinatal diet to modulate the gut microbiota increases dietary variety and prebiotic and probiotic food intakes
Bazi Bushen capsule modulates Akkermansia muciniphila and spermidine metabolism to attenuate brain aging in Samp8 mice
Banxia Xiexin Decoction Alleviates as Co-Depression Disease by Regulating the Gut Microbiome-Lipid Metabolic Axis
Tianwangbuxiandan decoction alleviates constipation and associated emotional disorders via regulating the brain-gut axis
A study on the effects of metacinnabar (β-HgS) on weight and appetite recovery in stressed mice
Dietary interventions, the gut microbiome, and aggressive behavior
Are adolescent diet quality and emotional eating predicted by history of maternal caregiving quality and concurrent inhibitory control
Fermented food consumption in wild nonhuman primates and its ecological drivers
Altered gut microbiota composition and feeding behaviours in children with Autism Spectrum Disorder
The dawn of ethnomicrobiology
One time my gut and psyche talked to each other
Abundance and absence
Gut Microbial Intersections with Human Ecology and Evolution
Diagnostic and Statistical Manual of Mental Disorders
The Statistical Analysis of Compositional Data
The economic cost of brain disorders in Europe
Schizophrenia
Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Mind-altering microorganisms
Gut–brain axis
An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
An obesity-associated gut microbiome with increased capacity for energy harvest
Healthy dietary indices and risk of depressive outcomes
How do you feel — now? The anterior insula and human awareness
Diet rapidly and reproducibly alters the human gut microbiome
Mortality Rates in Patients With Anorexia Nervosa and Other Eating Disorders
A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)
Neural regulation of endocrine and autonomic stress responses
Hypothalamic–pituitary–adrenal axis, neuroendocrine factors and stress
The Hallmarks of Aging
The Adolescent Brain
Adolescent mental health—Opportunity and obligation
Economic Burden of Obesity
Human gut microbiome viewed across age and geography
The adolescent brain and age-related behavioral manifestations
Critical Periods in Speech Perception
The Emotional Brain, Fear, and the Amygdala
Development of the adolescent brain
Why do many psychiatric disorders emerge during adolescence?
Molecular analyses of the intestinal microbiota of chimpanzees in the wild and in captivity
Fecal bacterial diversity of human‐habituated wild chimpanzees ( Pan troglodytes schweinfurthii ) at Mahale Mountains National Park, Western Tanzania
Brain Structure and Response to Emotional Stimuli as Related to Gut Microbial Profiles in Healthy Women
Peripheral catecholamine levels and the symptoms of anxiety
The Microbiome in Posttraumatic Stress Disorder and Trauma-Exposed Controls
Chronic Psychosocial Stress and Gut Health in Children
From Resilience to Vulnerability
Short Term Intrarectal Administration of Sodium Propionate Induces Antidepressant-Like Effects in Rats Exposed to Chronic Unpredictable Mild Stress
Mediterranean diet and depression
"Life in a Germ-Free World"
Dietary fiber intervention on gut microbiota composition in healthy adults
Acute Stressors and Cortisol Responses
| Unique citing works | 60 |
|---|---|
| Citations per year | 3 |
| Citation span | 2006 - 2026 (21) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 49 |