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Multi-Ethnic Study of Atherosclerosis

Objectives and Design

Bibliographic Data

ID23344993
AuthorsDiane E Bild (National Heart Lung and Blood Institute, corresponding author)
Year2002
Volume156
Issue9
Pages871-881
Publication date2002-11-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Epidemiology (JOURNAL)
Journal identifiersISSN: 0002-9262 • E-ISSN: 1476-6256
PublisherOxford University Press (OUP) (PUBLISHER)
DOI10.1093/aje/kwf113
PMID12397006
OpenAlexW2156097706
LanguageEN
Citations received114
References cited43

The Multi-Ethnic Study of Atherosclerosis was initiated in July 2000 to investigate the prevalence, correlates, and progression of subclinical cardiovascular disease (CVD) in a population-based sample of 6,500 men and women aged 45-84 years. The cohort will be selected from six US field centers. Approximately 38% of the cohort will be White, 28% African-American, 23% Hispanic, and 11% Asian (of Chinese descent). Baseline measurements will include measurement of coronary calcium using computed tomography; measurement of ventricular mass and function using cardiac magnetic resonance imaging; measurement of flow-mediated brachial artery endothelial vasodilation, carotid intimal-medial wall thickness, and distensibility of the carotid arteries using ultrasonography; measurement of peripheral vascular disease using ankle and brachial blood pressures; electrocardiography; and assessments of microalbuminuria, standard CVD risk factors, sociodemographic factors, life habits, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for use in nested case-control studies. DNA will be extracted and lymphocytes will be immortalized for genetic studies. Measurement of selected subclinical disease indicators and risk factors will be repeated for the study of progression over 7 years. Participants will be followed through 2008 for identification and characterization of CVD events, including acute myocardial infarction and other coronary heart disease, stroke, peripheral vascular disease, and congestive heart failure; therapeutic interventions for CVD; and mortality.

Cardiology · Cohort · Coronary artery disease · Heart failure · Myocardial infarction · Population · Stroke (engine) · Atherosclerosis and Cardiovascular Diseases · Cardiovascular Disease and Adiposity · Diabetes, Cardiovascular Risks, and Lipoproteins · Internal Medicine · Medicine

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Unique citing works114
Citations per year5,43
Citation span2005 - 2025 (21)
Citation velocityrecent
Highly citedYes
Citation typesNeutral: 99

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