Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Bibliographic Data
| ID | 23346232 |
|---|---|
| Authors | Patrick O McGowan (0000-0001-5459-5976, Douglas Mental Health University Institute), Aya Sasaki (0000-0001-8770-1341, Douglas Mental Health University Institute), Ana C D'Alessio, Ana C D’Alessio (McGill University), Sergiy Dymov (McGill University), Benoit Labonte (0000-0002-1251-5605, Douglas Mental Health University Institute), Moshe Szyf (0000-0003-3881-8214, McGill University, corresponding author), Gustavo Turecki (0000-0003-4075-2736, Douglas Mental Health University Institute, corresponding author), Michael J Meaney (0000-0002-8605-1997, Douglas Mental Health University Institute, corresponding author) |
| Year | 2009 |
| Volume | 12 |
| Issue | 3 |
| Pages | 342-348 |
| Publication date | 2009-03-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Nature Neuroscience (JOURNAL) |
| Journal identifiers | ISSN: 1097-6256 • E-ISSN: 1546-1726 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1038/nn.2270 |
| PMID | 19234457 |
| PMCID | PMC2944040 |
| OpenAlex | W2148337554 |
| Language | EN |
| Citations received | 217 |
| References cited | 48 |
Biology · Child abuse · DNA methylation · Epigenetics · FKBP5 · Gene · Gene expression · Glucocorticoid · Glucocorticoid receptor · Methylation · Poison control · Suicide prevention · Transcription factor · Early Childhood Education and Development · Endocrinology · Genetics · Internal Medicine · Medicine · Neuroendocrine regulation and behavior · Stress Responses and Cortisol
Altricialité
Childhood adversity and depressive symptoms in undergraduates
Social bodies and social justice
Early Human Development Equity from the Start Latin America
Epigenetic Risk Factors in PTSD and Depression
Emerging trends in epigenetic and childhood trauma
BDNF Gene's Role in Schizophrenia
Sex-Specific and Strain-Dependent Effects of Early Life Adversity on Behavioral and Epigenetic Outcomes
The Effects of Maternal Separation on Adult Methamphetamine Self-Administration, Extinction, Reinstatement, and MeCP2 Immunoreactivity in the Nucleus Accumbens
Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD
Neurobiology of Maternal Stress
Stress-induced epigenome changes as a risk factor in the onset of mental disorders
Interindividual Variability in Stress Susceptibility
Effects of Genotype and Child Abuse on DNA Methylation and Gene Expression at the Serotonin Transporter
Mantendo vivo o que já está morto
A psicologia como neurociência cognitiva
Governing through the Brain
Psicofármacos, drogas y neuro-gubernamentalidad. Legalidad y “la clínica”. ¿Quién gobierna la prescripción
Epigenética, Cuidados Maternais e Vulnerabilidade ao Estresse
Intergenerational transmission of self-regulation
A Generalized Selected Effects Theory of Function
When do adaptive developmental mechanisms yield maladaptive outcomes
The intergenerational transmission of parenting
Neuroscience, Molecular Biology, and the Childhood Roots of Health Disparities
Early Violence Exposure and Self-Regulatory Development
Behavioral Genetics
The Emerging Field of Social and Behavioral Epigenetics
Social Epigenetics
The Developmental Psychobiology of Stress and Emotion in Childhood
Neonatal Social Isolation
Social Epigenetics
Neonatal Temperament
Epigenetics
Engaging Native Americans in Genomics Research
What Biological Functions Are and Why They Matter
Understanding resilience
Biological memories of past environments
Decision making under stress
Epigenetics and the Biological Definition of Gene × Environment Interactions
Adolescent Violence Perpetration
I. Children in Institutional Care
Hair cortisol, stress exposure, and mental health in humans
Chronic stress, cognitive functioning and mental health
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Improving Mental Health Access for Low-Income Children and Families in the Primary Care Setting
Social influences on neuroplasticity
The Temporal Elements of Psychological Resilience
Advancing resilience
Adverse childhood experiences, allostasis, allostatic load, and age-related disease
Major depressive disorder
The Emerging Field of Human Social Genomics
The Devastating Clinical Consequences of Child Abuse and Neglect
Toxic Stress in Children and Adolescents
Suicide and suicidal behaviour
Social Safety Theory
Intergenerational transmission of trauma effects
Resilience in mental health
Psychobiology and molecular genetics of resilience
Childhood maltreatment and obesity
Suicide and suicide risk
Childhood trauma and adulthood inflammation
Neurobiological and Systemic Effects of Chronic Stress
The Biological Effects of Childhood Trauma
Socioeconomic status and the brain
State of the Art Review
Adolescent risk taking, impulsivity, and brain development
Epistemic modesty, ostentatiousness and the uncertainties of epigenetics: on the knowledge machinery of (social) science
Epigenetics and the Social Work Imperative
Trauma and Gene Expression
Epigenetic changes associated with multi-generational trauma
The emotional foundations of high moral intelligence
Pilot study suggests DNA methylation of the glucocorticoid receptor gene (NR3C1) is associated with MDMA-assisted therapy treatment response for severe PTSD
Identifying Four Subgroups of Trauma in Psychosis
An Empirical Theory of the Development of Homicide within Individuals
Impaired emotional awareness is associated with childhood maltreatment exposure and positive symptoms in schizophrenia
DNA Methylation in Healthy Older Adults With a History of Childhood Adversity—Findings From the Women 40+ Healthy Aging Study
The associations between adverse childhood experiences and body pain among middle-aged and older adults
Maternal Deprivation Increased Vulnerability to Depression in Adult Rats Through DRD2 Promoter Methylation in the Ventral Tegmental Area
Suicide Risk and Personality Traits in Physically and/or Sexually Abused Acute Psychiatric Inpatients
The mediating role of transmembrane protein 132D methylation in predicting the occurrence of panic disorder in physical abuse
Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents
Introducing the Neuroplastic Narrative
Predicting Health-Related Quality of Life in Trauma-Exposed Male Veterans in Late Midlife
Give me five! A modern perspective on addiction from the up-dated Freudian drive theory
When mummy and daddy get under your skin
Written in the Body
The relationship of maternal and child methylation of the glucocorticoid receptor NR3C1 during early childhood and subsequent child psychopathology at school-age in the context of maternal interpersonal violence-related post-traumatic stress disorder
Past Traumatic Life Events, Postpartum PTSD, and the Role of Labor Support
Childhood adverse events and BDNF promoter methylation in later-life
Approche psychopathologique de l’hyperactivité et pathologies limites chez l’enfant
Adverse Childhood Events and Health Biomarkers
Alexithymia and depressive symptoms mediated the relationship between childhood trauma and suicidal risk in Chinese male prisoners
Inherited Vulnerabilities and Innate Remedies
Clinical and Theoretical Reflections on Complex Developmental Trauma
Practitioner Review
The mediation effect of glucocorticoid receptor gene ( NR3C1 ) methylation between childhood maltreatment and depressive symptoms in Chinese adolescents
Mothers’ Attachment is Linked to Their Children’s Anti-Inflammatory Gene Expression via Maternal Warmth
A SNP , Gene, and Polygenic Risk Score Approach of Oxytocin‐Vasopressin Genes in Adolescents’ Loneliness
The Polygenomic Organism
Troubling Neurobiological Vulnerability
A Prospective Investigation of Major Depressive Disorder and Comorbidity in Abused and Neglected Children Grown Up
The role of childhood trauma in the neurobiology of mood and anxiety disorders
Stress and the brain
Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Epigenetic programming by maternal behavior
The Structured Clinical Interview for DSM-III-R (SCID)
Childhood Sexual Abuse and Psychiatric Disorder in Young Adulthood
Maternal Care, Gene Expression, and the Transmission of Individual Differences in Stress Reactivity Across Generations
| Unique citing works | 217 |
|---|---|
| Citations per year | 12,76 |
| Citation span | 2009 - 2026 (18) |
| Citation velocity | current |
| Highly cited | Yes |
| Citation types | Neutral: 193 |