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The Timing of Normal Puberty and the Age Limits of Sexual Precocity

Variations around the World, Secular Trends, and Changes after Migration

Bibliographic Data

ID23355014
AuthorsAnne-Simone Parent (University of Liège), Anne‐Simone Parent (0000-0002-4292-846X, University of Liège), Grete Teilmann (0000-0002-9874-2111, Department of Growth and Reproduction (G.T., A.J., N.E.S.), Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen Ø, Denmark), Anders Juul (0000-0002-0534-4350, Department of Growth and Reproduction (G.T., A.J., N.E.S.), Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen Ø, Denmark), Niels Erik Skakkebæk (0000-0002-4282-8020, Copenhagen University Hospital), Jorma Toppari (0000-0003-2228-334X, Departments of Paediatrics and Physiology (J.T.), University of Turku, 20520 Turku, Finland), Jean-Pierre Bourguignon (University of Liège, corresponding author)
Year2003
Volume24
Issue5
Pages668-693
Publication date2003-10-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueEndocrine Reviews (JOURNAL)
Journal identifiersISSN: 0163-769X • E-ISSN: 1945-7189
PublisherThe Endocrine Society (PUBLISHER)
DOI10.1210/er.2002-0019
PMID14570750
OpenAlexW2153589742
LanguageEN
Citations received129
References cited200

During the past decade, possible advancement in timing of puberty has been reported in the United States. In addition, early pubertal development and an increased incidence of sexual precocity have been noticed in children, primarily girls, migrating for foreign adoption in several Western European countries. These observations are raising the issues of current differences and secular trends in timing of puberty in relation to ethnic, geographical, and socioeconomic background. None of these factors provide an unequivocal explanation for the earlier onset of puberty seen in the United States. In the formerly deprived migrating children, refeeding and catch-up growth may prime maturation. However, precocious puberty is seen also in some nondeprived migrating children. Attention has been paid to the changing milieu after migration, and recently, the possible role of endocrine- disrupting chemicals from the environment has been considered. These observations urge further study of the onset of puberty as a possible sensitive and early marker of the interactions between environmental conditions and genetic susceptibility that can influence physiological and pathological processes.

Biology · Ethnic group · Hormone · Political science · Population · Precocious puberty · Secular variation · Sexual maturity · Socioeconomic status · Birth, Development, and Health · Demography · Endocrinology · Growth Hormone and Insulin-like Growth Factors · Hypothalamic control of reproductive hormones

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Unique citing works129
Citations per year6,14
Citation span2005 - 2025 (21)
Citation velocityrecent
Highly citedYes
Citation typesNeutral: 109

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