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High Blood Pressure and Cardiovascular Disease

Bibliographic Data

ID23357232
AuthorsFlavio Danni Fuchs (0000-0002-1191-0523, Universidade Federal do Rio Grande do Sul), Paul K Whelton (0000-0002-2225-383X, Departments of Epidemiology and Medicine, Tulane University, New Orleans, LA (P.K.W.)., corresponding author)
Year2020
Volume75
Issue2
Pages285-292
Publication date2020-02-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueHypertension (JOURNAL)
Journal identifiersISSN: 0194-911X • E-ISSN: 1524-4563
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1161/hypertensionaha.119.14240
PMID31865786
OpenAlexW2998223455
LanguageEN
Citations received61
References cited57

Fragmented investigation has masked the overall picture for causes of cardiovascular disease (CVD). Among the risk factors for CVD, high blood pressure (BP) is associated with the strongest evidence for causation and it has a high prevalence of exposure. Biologically, normal levels of BP are considerably lower than what has typically been characterized as normal in research and clinical practice. We propose that CVD is primarily caused by a right-sided shift in the population distribution of BP. Our view that BP is the predominant risk factor for CVD is based on conceptual postulates that have been tested in observational investigations and clinical trials. Large cohort studies have demonstrated that high BP is an important risk factor for heart failure, atrial fibrillation, chronic kidney disease, heart valve diseases, aortic syndromes, and dementia, in addition to coronary heart disease and stroke. In multivariate modeling, the presumed attributable risk of high BP for stroke and coronary heart disease has increased steadily with progressive use of lower values for normal BP. Meta-analysis of BP-lowering randomized controlled trials has demonstrated a benefit which is almost identical to that predicted from BP risk relationships in cohort studies. Prevention of age-related increases in BP would, in large part, reduce the vascular consequences usually attributed to aging, and together with intensive treatment of established hypertension would eliminate a large proportion of the population burden of BP-related CVD.

Atrial fibrillation · Blood pressure · Cardiology · Cohort · Cohort study · Coronary artery disease · Dementia · Disease · Heart failure · Kidney disease · Observational study · Population · Risk factor · Stroke (engine) · Blood Pressure and Hypertension Studies · Cardiovascular Health and Disease Prevention · Heart Rate Variability and Autonomic Control · Internal Medicine · Medicine

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Unique citing works61
Citations per year12,2
Citation span2021 - 2026 (6)
Citation velocitycurrent
Highly citedNo
Citation typesNeutral: 57

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