The Multicenter Aids Cohort Study

Rationale, Organization, and Selected Characteristics of the Participants

Bibliographic Data

ID23360528
AuthorsRichard A Kaslow (National Institute of Allergy and Infectious Diseases, corresponding author), David G Ostrow (Northwestern University), Roger Detels (0000-0002-6622-9655, UCLA Health), John Phair (0000-0003-2464-5957, Northwestern University), J P Phair, B Frank Polk (Johns Hopkins University), Charles R Rinaldo (0000-0002-9194-3164, University of Pittsburgh), FOR THE MULTICENTER AIDS COHORT STUDY
Year1987
Volume126
Issue2
Pages310-318
Publication date1987-08-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Epidemiology (JOURNAL)
Journal identifiersISSN: 0002-9262 • E-ISSN: 1476-6256
PublisherOxford University Press (OUP) (PUBLISHER)
DOI10.1093/aje/126.2.310
PMID3300281
OpenAlexW2170821252
LanguageEN
Citations received77

The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the infection, and establish a repository of biologic specimens for future study. A variety of recruitment techniques, including special assurance of confidentiality, were used to enroll participants. Nearly 5,000 homosexual men volunteered for semiannual interview, physical examination, and laboratory testing in four metropolitan areas. A significant majority of these men in each center (69-83%) reported having 50 or more lifetime sexual partners, and over 80% had engaged in receptive anal intercourse with at least some of their partners in the previous two years. By the time of the participants' initial evaluation (April 1984-April 1985), infection with the human immunodeficiency virus (HIV) had occurred in higher proportions of men in Los Angeles (51%) and Chicago (43%) than in Baltimore/Washington, DC (31%) and Pittsburgh (21%), presumably as a result of the higher number of partners and proportion with whom these men had engaged in high-risk practices (e.g., receptive anal intercourse). Follow-up evaluations are underway in this comprehensive longitudinal investigation of HIV infection.

Cohort · Cohort study · Confidentiality · Family medicine · Human immunodeficiency virus (HIV) · Multicenter AIDS Cohort Study · Multicenter study · Natural history · Sida · Viral disease · Adolescent Sexual and Reproductive Health · Demography · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Internal Medicine · Medicine · Gerontology

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