Alcohol consumption and site-specific cancer risk

A comprehensive dose–response meta-analysis

Datos Bibliográficos

ID23367188
AutoresVincenzo Bagnardi (0000-0002-4938-3482, European Institute of Oncology, autor de correspondencia), Matteo Rota (0000-0003-3928-5966, University of Milano-Bicocca), Edoardo Botteri (0000-0002-9023-8068, Ripamonti), Irene Tramacere (0000-0001-5550-3412, The Neurological Institute), Farhad Islami (0000-0002-7357-5994, Shariati Hospital), Veronika Fedirko (0000-0002-7805-9913, Emory University), Lorenza Scotti (0000-0002-3861-9058, University of Milano-Bicocca), Mazda Jenab (0000-0002-0573-1852, Centre international de recherche sur le cancer), Federica Turati (0000-0002-5841-5773, Mario Negri Institute for Pharmacological Research), Elena Pasquali (Ripamonti), Claudio Pelucchi (0000-0003-1425-8945, Mario Negri Institute for Pharmacological Research), Carlotta Galeone (0000-0003-1934-5167, Mario Negri Institute for Pharmacological Research), Rino Bellocco (0000-0002-2538-0287, Karolinska Institutet), Eva Negri (0000-0001-9712-8526, Mario Negri Institute for Pharmacological Research), Giovanni Corrao (0000-0002-1034-8444, University of Milano-Bicocca), Paolo Boffetta (0000-0002-3811-2791, Icahn School of Medicine at Mount Sinai), Carlo La Vecchia (0000-0003-1441-897X, University of Milan)
Año2015
Volumen112
Número3
Páginas580-593
Fecha de publicación2015-02-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaBritish Journal of Cancer (JOURNAL)
Identificadores de la revistaISSN: 0007-0920 • E-ISSN: 1532-1827
EditorialSpringer Science and Business Media LLC (PUBLISHER)
DOI10.1038/bjc.2014.579
PMID25422909
PMCIDPMC4453639
OpenAlexW1965385210
IdiomaEN
Citas recibidas65
Referencias citadas61

BACKGROUND: Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial. METHODS: We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose-response meta-regression models and investigated potential sources of heterogeneity. RESULTS: A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose-risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin's and Non-Hodgkin's lymphomas were inversely associated. CONCLUSIONS: Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.

Alcohol · Alcohol consumption · Bioinformatics · Biology · Meta-analysis · Alcohol Consumption and Health Effects · Carcinogens and Genotoxicity Assessment · Head and Neck Cancer Studies · Internal Medicine · Medicine · Oncology