Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults

A Systematic Review and Meta-analysis

Datos Bibliográficos

ID23385114
AutoresArchiman Biswas (0000-0002-0393-6280, Sunnybrook Health Science Centre), Aviroop Biswas (From the Institute of Health Policy, Management and Evaluation, and the Faculty of Kinesiology and Physical Education, University of Toronto; University Health Network–Toronto Rehabilitation Institute, Cardiovascular Prevention and Rehabilitation Program; Sunnybrook Health Sciences Centre; York University; and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.), Paul Oh (0000-0002-0603-6958, Sunnybrook Health Science Centre), Paul I Oh (From the Institute of Health Policy, Management and Evaluation, and the Faculty of Kinesiology and Physical Education, University of Toronto; University Health Network–Toronto Rehabilitation Institute, Cardiovascular Prevention and Rehabilitation Program; Sunnybrook Health Sciences Centre; York University; and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.), G Faulkner (0000-0001-8898-2536, Sunnybrook Health Science Centre), Guy E Faulkner (From the Institute of Health Policy, Management and Evaluation, and the Faculty of Kinesiology and Physical Education, University of Toronto; University Health Network–Toronto Rehabilitation Institute, Cardiovascular Prevention and Rehabilitation Program; Sunnybrook Health Sciences Centre; York University; and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.), R Bajaj (0000-0001-9058-0931, Sunnybrook Health Science Centre), Ravi R Bajaj (From the Institute of Health Policy, Management and Evaluation, and the Faculty of Kinesiology and Physical Education, University of Toronto; University Health Network–Toronto Rehabilitation Institute, Cardiovascular Prevention and Rehabilitation Program; Sunnybrook Health Sciences Centre; York University; and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.), Michael A Silver (0000-0002-7145-5657, From the Institute of Health Policy, Management and Evaluation, and the Faculty of Kinesiology and Physical Education, University of Toronto; University Health Network–Toronto Rehabilitation Institute, Cardiovascular Prevention and Rehabilitation Program; Sunnybrook Health Sciences Centre; York University; and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.), Marc Mitchell (0000-0002-2772-9614, Sunnybrook Health Science Centre), Marc S Mitchell (From the Institute of Health Policy, Management and Evaluation, and the Faculty of Kinesiology and Physical Education, University of Toronto; University Health Network–Toronto Rehabilitation Institute, Cardiovascular Prevention and Rehabilitation Program; Sunnybrook Health Sciences Centre; York University; and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.), David A Alter (0000-0002-5722-0202, From the Institute of Health Policy, Management and Evaluation, and the Faculty of Kinesiology and Physical Education, University of Toronto; University Health Network–Toronto Rehabilitation Institute, Cardiovascular Prevention and Rehabilitation Program; Sunnybrook Health Sciences Centre; York University; and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.)
Año2015
Volumen162
Número2
Páginas123-132
Fecha de publicación2015-01-20
Peer ReviewedSí
Open AccessNo
TipoARTICLE
RevistaAnnals of Internal Medicine (JOURNAL)
Identificadores de la revistaISSN: 0003-4819 • E-ISSN: 1539-3704
EditorialAmerican College of Physicians (PUBLISHER • US)
DOI10.7326/m14-1651
PMID25599350
OpenAlexW1972643702
IdiomaEN
Citas recibidas273
Referencias citadas56

BACKGROUND: The magnitude, consistency, and manner of association between sedentary time and outcomes independent of physical activity remain unclear. PURPOSE: To quantify the association between sedentary time and hospitalizations, all-cause mortality, cardiovascular disease, diabetes, and cancer in adults independent of physical activity. DATA SOURCES: English-language studies in MEDLINE, PubMed, EMBASE, CINAHL, Cochrane Library, Web of Knowledge, and Google Scholar databases were searched through August 2014 with hand-searching of in-text citations and no publication date limitations. STUDY SELECTION: Studies assessing sedentary behavior in adults, adjusted for physical activity and correlated to at least 1 outcome. DATA EXTRACTION: Two independent reviewers performed data abstraction and quality assessment, and a third reviewer resolved inconsistencies. DATA SYNTHESIS: Forty-seven articles met our eligibility criteria. Meta-analyses were performed on outcomes for cardiovascular disease and diabetes (14 studies), cancer (14 studies), and all-cause mortality (13 studies). Prospective cohort designs were used in all but 3 studies; sedentary times were quantified using self-report in all but 1 study. Significant hazard ratio (HR) associations were found with all-cause mortality (HR, 1.240 [95% CI, 1.090 to 1.410]), cardiovascular disease mortality (HR, 1.179 [CI, 1.106 to 1.257]), cardiovascular disease incidence (HR, 1.143 [CI, 1.002 to 1.729]), cancer mortality (HR, 1.173 [CI, 1.108 to 1.242]), cancer incidence (HR, 1.130 [CI, 1.053 to 1.213]), and type 2 diabetes incidence (HR, 1.910 [CI, 1.642 to 2.222]). Hazard ratios associated with sedentary time and outcomes were generally more pronounced at lower levels of physical activity than at higher levels. LIMITATION: There was marked heterogeneity in research designs and the assessment of sedentary time and physical activity. CONCLUSION: Prolonged sedentary time was independently associated with deleterious health outcomes regardless of physical activity. PRIMARY FUNDING SOURCE: None.

CINAHL · Cochrane Library · Cohort study · Confidence interval · Diabetes mellitus · Disease · Hazard ratio · Incidence (geometry) · MEDLINE · Meta-analysis · Obesity · Prospective cohort study · Sedentary lifestyle · Type 2 diabetes · Cardiovascular and exercise physiology · Endocrinology · Internal Medicine · Medicine · Mobile Health and mHealth Applications · Physical Activity and Health · Gerontology