Outcomes of Combined Liver–Kidney Transplantation in Children
Analysis of the Scientific Registry of Transplant Recipients
Bibliographic Data
| ID | 23401730 |
|---|---|
| Authors | Clement Greenberg (corresponding author), A M Calinescu, B E Wildhaber, A PONCET, C Toso, V A McLin |
| Year | 2014 |
| Volume | 14 |
| Issue | 12 |
| Pages | 2861-2868 |
| Publication date | 2014-12-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Transplantation (JOURNAL) |
| Journal identifiers | ISSN: 1600-6135 • E-ISSN: 1600-6143 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1111/ajt.12935 |
| PMID | 25274400 |
| OpenAlex | W25274400 |
| Language | EN |
| Citations received | 6 |
| References cited | 17 |
Combined liver-kidney transplantation (CLKT) in children is uncommon and outcomes have not been well defined. Using the Scientific Registry of Transplant Recipients, data were analyzed on 152 primary pediatric CLKTs performed from October 1987 to February 2011, to determine their outcome in the largest series reported to date. Patient survival was 86.8%, 82.1% and 78.9% at 1, 5 and 10 years, liver graft survival was 81.9%, 76.5% and 72.6%, and kidney graft survival was 83.4%, 76.5% and 66.8%. By way of comparison, the Registry was queried for pediatric patient survival following isolated liver transplantation (LT) during the same time frame: 86.7%, 81.2% and 77.4% and following isolated kidney transplant (KT): 98.2%, 95.4% and 90% at 1, 5 and 10 years. In patients having undergone CLKT, primary hyperoxaluria was associated with reduced patient (p = 0.01), liver graft (p = 0.01) and kidney graft survival (p = 0.01). Furthermore, graft outcome following CLKT improved over the past decade (p = 0.04 for liver, p = 0.02 for kidney), but this did not translate into improved patient outcome (p = 0.2). All in all, our results confirmed that survival following LT was less than following KT, and that CLKT offered similar patient survival to isolated LT.
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| Unique citing works | 6 |
|---|---|
| Citations per year | 0,26 |
| Citation span | 2003 - 2021 (19) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |