Biomarkers for Screening, Diagnosis, and Monitoring of Ovarian Cancer

Bibliographic Data

ID23519628
AuthorsEiji Kobayashi (Authors' Affiliation: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan), Yutaka Ueda (0000-0001-8760-6379, Authors' Affiliation: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan), Shinya Matsuzaki (Authors' Affiliation: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan), Takuhei Yokoyama (Authors' Affiliation: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan), Toshihiro Kimura (Authors' Affiliation: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan), Kiyoshi Yoshino (0000-0002-5732-5215, Authors' Affiliation: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan), Masami Fujita (0000-0002-6535-0795, Authors' Affiliation: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan), Tadashi Kimura (0000-0003-1279-9078, Authors' Affiliation: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan), Takayuki Enomoto (0000-0003-4538-5541, Authors' Affiliation: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan)
Year2012
Volume21
Issue11
Pages1902-1912
Publication date2012-11-01
Open AccessNo
TypeARTICLE
VenueCancer Epidemiology, Biomarkers & Prevention (JOURNAL)
Journal identifiersISSN: 1055-9965 • E-ISSN: 1538-7755
PublisherAmerican Association for Cancer Research (AACR) (PUBLISHER)
DOI10.1158/1055-9965.epi-12-0646
PMID22962405
OpenAlexW22962405
LanguageEN
Citations received1
References cited70

Serum tumor markers have a major role in the screening, diagnosis, and monitoring of most of the gynecologic cancers. Ovarian cancer is one of the deadliest of the group because it is so frequently asymptomatic until it has advanced to an untreatable stage. Even serum cancer antigen-125 (CA-125), clinically one of the most reliable serum markers for ovarian cancer, is elevated in only half of early-stage still-treatable tumors. Because of the very low prevalence of ovarian cancer in the general population, at present, there is no cost-effective imaging or simple microscopic screening test for ovarian cancer as there is for breast and cervical cancers. However, recent proteomics and nucleic acid–based analyses have shown great promise for the discovery of new and more useful serum biomarkers, which cumulatively might provide such a screening tool. In this review, we will discuss both the currently used serum tumor markers for screening, diagnosis, monitoring of ovarian cancer, and the novel biomarkers that are now under investigation and validation. Cancer Epidemiol Biomarkers Prev; 21(11); 1902–12. ©2012 AACR.

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