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Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region

Bibliographic Data

ID23533698
AuthorsKimberly Chabot Davis (corresponding author), Rafael Affini Martins (Universidade Federal de São Paulo), Dandara Cassu-Corsi (0000-0002-9162-9677, Universidade Federal de São Paulo), Carolina Silva Nodari (Universidade Federal de São Paulo), Rodrigo Cayô (0000-0002-0709-6282, Universidade Federal de São Paulo), Larissa Natsumeda (Universidade Federal de São Paulo), Ana Paula Streling (Universidade Federal de São Paulo), André Mario Doi (Universidade Federal de São Paulo), Roberto José Carvalho da Silva (Centro de Referência e Tratamento de Doenças Sexualmente Transmissíveis, Brasil), Roberta Alessandra Lima Bocalon (Centro de Referência e Tratamento de Doenças Sexualmente Transmissíveis, Brasil), Ana Cristina GALES (0000-0003-0913-768X, Universidade Federal de São Paulo), Antonio Carlos Campos Pignatari (0000-0002-2146-8476, Universidade Federal de São Paulo)
Year2019
Volume114
Pagese190079-e190079
Publication date2019-01-01
Open AccessYes
TypeARTICLE
VenueMemórias do Instituto Oswaldo Cruz (JOURNAL)
Journal identifiersISSN: 0074-0276 • E-ISSN: 1678-8060
PublisherFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/0074-02760190079
OpenAlexW31411309
SciELOS0074-02762019000100414
LanguageEN
Citations received6
References cited10

A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, and a C2611T substitution on 23S rRNA alleles was also observed in isolate 260. Both isolates belonged to ST1901/ST6210 (MSLT/NG-MAST schemes).

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Citations per year0.6
Citation span2016 - 2022 (7)
Highly citedNo

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