Dietary Supplementation of Haskap Berry (Lonicera caerulea L.) Anthocyanins and Probiotics Attenuate Dextran Sulfate Sodium-Induced Colitis
Evidence from an Experimental Animal Model
Bibliographic Data
| ID | 23537468 |
|---|---|
| Authors | K V Surangi Dharmawansa (Dalhousie University), Andrew W Stadnyk (0000-0002-1940-8036, Dalhousie University), H P Vasantha Rupasinghe (0000-0003-3435-0052, Dalhousie University) |
| Year | 2024 |
| Volume | 13 |
| Issue | 13 |
| Pages | 1987 |
| Publication date | 2024-06-24 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Foods (JOURNAL) |
| Journal identifiers | ISSN: 2304-8158 • E-ISSN: 2304-8158 |
| Publisher | MDPI AG (PUBLISHER • IT) |
| DOI | 10.3390/foods13131987 |
| OpenAlex | W38998493 |
| Language | EN |
| Citations received | 5 |
| References cited | 70 |
Haskap berry (Lonicera caerulea L.) is a rich dietary source of anthocyanins with potent anti-inflammatory properties. In this study, isolated haskap berry anthocyanins were encapsulated in maltodextrin and inulin (3:1) by freeze-drying to improve stability and bioavailability. The structural properties of microcapsules, encapsulation yield, efficiency, recovery, and powder retention were evaluated. The microcapsules that exhibited the highest encapsulation efficiency (60%) and anthocyanin recovery (89%) were used in the dextran sulfate sodium (DSS)-induced acute colitis in mice. Thirty-five BALB/c male mice of seven weeks old were divided into seven dietary supplementation groups (n = 5) to receive either free anthocyanins, encapsulated anthocyanins (6.2 mg/day), or probiotics (1 × 109 CFU/day) alone or as combinations of anthocyanin and probiotics. As observed by clinical data, free anthocyanin and probiotic supplementation significantly reduced the severity of colitis. The supplementary diets suppressed the DSS-induced elevation of serum inflammatory (interleukin (IL)-6 and tumor necrosis factor) and apoptosis markers (B-cell lymphoma 2 and Bcl-2-associated X protein) in mice colon tissues. The free anthocyanins and probiotics significantly reduced the serum IL-6 levels. In conclusion, the dietary supplementation of haskap berry anthocyanins and probiotics protects against DSS-induced colitis possibly by attenuating mucosal inflammation, and this combination has the potential as a health-promoting dietary supplement and nutraceutical.
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| Citations per year | 0.63 |
|---|---|
| Citation span | 2018 - 2025 (8) |
| Highly cited | No |