Microdosing with classical psychedelics

Research trajectories and practical considerations

Dados Bibliográficos

ID2395518
AutoresAlice Wong (0000-0002-1636-4680, Chapman University), Aviad Raz (0000-0001-9794-5470, Chapman University), Amir Raz (Chapman University)
Ano2022
Volume59
Fascículo5
Páginas675-690
Data de publicação2022-10-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoTranscultural Psychiatric Research Review (JOURNAL)
Identificadores do periódicoISSN: 0041-1108 • E-ISSN: 0315-4386
EditoraSAGE Publications Inc (PUBLISHER)
DOI10.1177/13634615221129115
PMID36317302
OpenAlexW4307758883
IdiomaEN
Citações recebidas3
Referências citadas75

Microdosing-the intermittent ingestion of minute, sub-hallucinogenic amounts of psychedelic substances, repeatedly and over time-has become a widespread, albeit largely understudied, phenomenon. Regulations around using psychedelics at any dose-micro, mini, macro, or mega-pose all sorts of difficulties for those who wish to systematically study the effects of Schedule I drugs, especially in the United States. Microdosers commonly claim that taking a sub-hallucinogenic (pre-hallucinogenic or sub-perceptual) dose improves higher brain functions, including creativity, productivity, and mood. If true, these results would provide an important experimental edge in distinguishing psychosocial effects (e.g. caused by expectation) from those related to the active psychedelic ingredient. In this critical integrative synthesis, we explore the psychobiological science of dose amounts and how it informs microdosing with classical psychedelics (e.g. lysergic acid diethylamide [LSD] and psilocybin) to highlight and fuel research into questions (e.g. in cognitive neuroscience, consciousness studies, and metacognition). We sketch the hurdle-laden regulatory landscape and the procedures that shroud research with Schedule I drugs. Finally, we offer some future directions relevant to both scholars and clinicians in the social and behavioral sciences as well as in mental health and neurological science

Consciousness · Hallucinogen · Lysergic acid diethylamide · Mescaline · Perception · Psilocybin · Psychiatry · Chemical synthesis and alkaloids · Medicine · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychedelics and Drug Studies · Psychology