Effect of self-reported walking difficulty on bone mass and bone resorption marker in Japanese people aged 40 years and over

Bibliographic Data

ID24312718
AuthorsYasuyo Abe (0000-0003-1429-9886), Takayuki Nishimura (0000-0001-5791-7512), Kazuhiko Arima (0000-0003-1149-9428), Mitsuo Kanagae, Satoshi Mizukami (0000-0002-9097-2115), Yoshihito Tomita (0000-0002-8401-8413), Takuhiro Okabe (0000-0003-3360-5068), Hisashi Goto, Itsuko Horiguchi, Kiyoshi Aoyagi (0000-0002-8163-7606)
Year2016
Volume35
Issue1
Pages25-25
Publication date2016-12-01
Open AccessYes
TypeARTICLE
VenueJournal of PHYSIOLOGICAL ANTHROPOLOGY (JOURNAL)
Journal identifiersISSN: 1880-6791 • E-ISSN: 1880-6805
PublisherSpringer Science and Business Media LLC (PUBLISHER)
DOI10.1186/s40101-016-0114-6
PMID27729080
OpenAlexW2529902976
LanguageEN
Citations received3
References cited27

BACKGROUND: This study aimed to examine the association of walking difficulty with bone mass or bone turnover among community-dwelling Japanese people aged 40 years and older. METHODS: We studied 1097 community-dwelling Japanese people aged 40 years and older (379 men and 718 women) who were invited to participate in periodic health examinations in 2006-2009. Walking difficulty was defined as having difficulty walking 100 m on a level surface (self-administered questionnaire). Calcaneal stiffness index (bone mass) was measured by quantitative ultrasound. Spot urine samples were collected, and urinary N-terminal cross-linking telopeptide of type I collagen (NTx) was measured. Values were corrected for creatinine (Cre) concentration. RESULTS: The prevalence of walking difficulty was significantly higher in women than in men (7.4 vs. 3.4 %, p = 0.011) and significantly increased with age in men (p for trend = 0.02) and women (p for trend <0.001). In univariate analysis, men and women with walking difficulty were older (p < 0.001) and had a lower stiffness index (p < 0.001), compared with those without walking difficulty. Among women, individuals with walking difficulty had significantly higher urinary NTx/Cre than those without walking difficulty (p < 0.001); however, this was not so among men (p = 0.39). Multiple regression analysis adjusted for age, weight, and menopausal status showed a significant association between walking difficulty and lower stiffness index in men (p = 0.004) and women (p = 0.005). In women, walking difficulty was significantly associated with higher NTx/Cre (p = 0.001), but not in men (p = 0.35). CONCLUSIONS: Walking difficulty may contribute to low bone mass in both sexes but might cause high bone turnover in women only.

Bone mass · Bone resorption · bone turnover · community-dwelling older adults · Japanese population · Menopause · older adults · quantitative ultrasound · Sex differences · walking difficulty · Balance, Gait, and Falls Prevention · Bone health and osteoporosis research · Nutrition and Health in Aging