New contribution on the LRRK2 G2019S mutation associated to Parkinson's disease
Age estimation of a common founder event of old age in Moroccan Berbers
Bibliographic Data
| ID | 2640898 |
|---|---|
| Authors | G Lucotte (corresponding author), D David (0000-0003-2293-590X), Nathalie Change |
| Year | 2012 |
| Volume | 1 |
| Issue | 5 |
| Publication date | 2012-05-23 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Modern Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 1737-7374 • E-ISSN: 1737-8176 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ijma.v1i5.1 |
| OpenAlex | W2045048482 |
| Language | EN |
| References cited | 2 |
Background: The LRRK2 G2019S mutation is an important genetic determinant of Parkinson’s disease (PD) across the world that occurs at an elevated frequency in North Africa. Aim: To estimate the date of the G2019S mutation in Berbers. Material and Methods: We determined the LRRK2 haplotypes in twenty-two G2019S carriers, mostly North Africans, and in one hundred twenty-four Arab, Moroccan Berber and Sephardi Jew controls, using seven microsatellite and two SNP genetic markers. Results: A single haplotype was detected, with some variations, in all mutation carriers. Using a maximum–likelihood method, we estimate that Moroccan Berbers with G2019S share a common ancestor who lived ~128 (95% CI 107-180) generations ago. Conclusion: Our conclusion is that the G2019S mutation of the LRRK2 gene originates 3,840 (95% CI 3,210-5,400) years ago in parkinsonian Moroccan Berbers patients.Key words: Parkinson’s disease (PD), Leucine-rich repeat kinase 2 (LRRK2) gene, G2019S mutation, Haplotype, Founding mutation
Allele · Biology · Founder effect · Gene · Haplotype · LRRK2 · Mutation · Banana Cultivation and Research · Demography · Genetics · Lysosomal Storage Disorders Research · Parkinson's Disease Mechanisms and Treatments
| Highly cited | No |
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