Adeno-associated virus 2 infection in children with non-A–E hepatitis

Dados Bibliográficos

AUTOR(ES) Antonia Ho , Richard Orton , Rachel Tayler , Patawee Asamaphan , Vanessa Herder , Chris Davis , Lily Tong , Katherine Smollett , Maria Manali , Jay Allan , Konrad Rawlik , Sarah E. McDonald , Elen Vink , Louisa Pollock , Louise Gannon , Clair Evans , Jim McMenamin , Kirsty Roy , Kimberly Marsh , Titus Divala , Matthew T. G. Holden , Michael Lockhart , David Yirrell , Sandra Currie , Maureen O’Leary , David Henderson , Samantha J. Shepherd , Celia Jackson , Rory Gunson , Alasdair MacLean , Neil McInnes , Amanda Bradley-Stewart , Richard Battle , Jill A. Hollenbach , Paul Henderson , Miranda Odam , Primrose Chikowore , Wilna Oosthuyzen , Meera Chand , Melissa Shea Hamilton , Diego Estrada-Rivadeneyra , Michael Levin , Nikos Avramidis , Erola Pairo-Castineira , Veronique Vitart , Craig Wilkie , Aubrey Cunnington , Jethro Herberg , Myrsini Kaforou , Victoria Wright , Evangelos Bellos , Claire Broderick , Samuel Channon-Wells , Samantha Cooray , Tisham De , Giselle D’Souza , Leire Estramiana Elorrieta , Rachel Galassini , Dominic Habgood-Coote , Shea Hamilton , Heather Jackson , James Kavanagh , Mahdi Moradi Marjaneh , Stephanie Menikou , Samuel Nichols , Ruud Nijman , Harsita Patel , Ivana Pennisi , Oliver Powell , Ruth Reid , Priyen Shah , Ortensia Vito , Elizabeth Whittaker , Clare Wilson , Rebecca Womersley , Amina Abdulla , Sarah Darnell , Sobia Mustafa , Pantelis Georgiou , Jesus-Rodriguez Manzano , Nicolas Moser , Michael Carter , Shane Tibby , Jonathan Cohen , Francesca Davis , Julia Kenny , Paul Wellman , Marie White , Matthew Fish , Aislinn Jennings , Manu Shankar-Hari , Katy Fidler , Dan Agranoff , Vivien Richmond , Mathew Seal , Saul Faust , Dan Owen , Ruth Ensom , Sarah McKay , Diana Mondo , Mariya Shaji , Rachel Schranz , Prita Rughnani , Amutha Anpananthar , Susan Liebeschuetz , Anna Riddell , Nosheen Khalid , Ivone Lancoma Malcolm , Teresa Simagan , Mark Peters , Alasdair Bamford , Lauran O’Neill , Nazima Pathan , Esther Daubney , Deborah White , Melissa Heightman , Sarah Eisen , Terry Segal , Lucy Wellings , Simon B. Drysdale , Nicole Branch , Lisa Hamzah , Heather Jarman , Maggie Nyirenda , Lisa Capozzi , Emma Gardiner , Robert Moots , Magda Nasher , Anita Hanson , Michelle Linforth , Sean O’Riordan , Donna Ellis , Akash Deep , Ivan Caro , Fiona Shackley , Arianna Bellini , Stuart Gormley , Samira Neshat , Barnaby J. Scholefield , Ceri Robbins , Helen Winmill , Stéphane C. Paulus , Andrew J. Pollard , Mark Anthony , Sarah Hopton , Danielle Miller , Zoe Oliver , Sally Beer , Bryony Ward , Shrijana Shrestha , Meeru Gurung , Puja Amatya , Bhishma Pokhrel , Sanjeev Man Bijukchhe , Tim Lubinda , Sarah Kelly , Peter O’Reilly , Federico Martinón-Torres , Antonio Salas , Fernando Álvez González , Xabier Bello , Mirian Ben García , Sandra Carnota , Miriam Cebey-López , María José Curras-Tuala , Carlos Durán Suárez , Luisa García Vicente , Alberto Gómez‐Carballa , Jose Gómez Rial , Pilar Leboráns Iglesias , Nazareth Martinón-Torres , José María Martinón Sánchez , Belén Mosquera Pérez , Jacobo Pardo-Seco , Lidia Piñeiro Rodríguez , Sara Pischedda , Sara Rey Vázquez , Irene Rivero Calle , Carmen Rodríguez-Tenreiro , Lorenzo Redondo-Collazo , Miguel Sadiki Ora , Sonia Serén Fernández , Cristina Serén Trasorras , Marisol Vilas Iglesias , Enitan D. Carrol , Elizabeth Cocklin , Aakash Khanijau , Rebecca Lenihan , Nadia Lewis-Burke , Karen Newall , Sam Romaine , Maria Tsolia , Irini Eleftheriou , Nikos Spyridis , Maria Tambouratzi , Despoina Maritsi , Antonios Marmarinos , Marietta Xagorari , Lourida Panagiota , Pefanis Aggelos , Akinosoglou Karolina , Gogos Charalambos , Maragos Markos , Voulgarelis Michalis , Stergiou Ioanna , Marieke Emonts , Emma Lim , John Isaacs , Kathryn Bell , Stephen Crulley , Daniel Fabian , Evelyn Thomson , Diane Wallia , Caroline Miller , Ashley Bell , Fabian J. S. van der Velden , Geoff Shenton , Ashley Price , Owen Treloar , Daisy Thomas , Pablo Rojo , Cristina Epalza , Serena Villaverde , Sonia Márquez , Manuel Gijón , Fátima Machín , Laura Cabello , Irene Hernández , Lourdes Gutiérrez , Ángela Manzanares , T. W. Taco Kuijpers , M. Martijn van de Kuip , A. M. Marceline van Furth , J. M. Merlijn van den Berg , Giske Biesbroek , Floris Verkuil , Carlijn C. W. van der Zee , Dasja Pajkrt , Michael Boele van Hensbroek , Dieneke Schonenberg , Mariken Gruppen , Sietse Nagelkerke , Machiel H. Jansen , Ines Goetschalckx , Lorenza Romani , Maia De Luca , Sara Chiurchiù , Martina Di Giuseppe , Clementien L. Vermont , Henriëtte A. Moll , Dorine M. Borensztajn , Nienke N. Hagedoorn , Chantal Tan , Joany Zachariasse , Medical students , W. Dik , Ching-Fen Kitty Shen , Dace Zavadska , Sniedze Laivacuma , Aleksandra Rudzate , Diana Stoldere , Arta Barzdina , Elza Barzdina , Monta Madelane , Dagne Gravele , Dace Svile , Romain Basmaci , Noémie Lachaume , Pauline Bories , Raja Ben Tkhayat , Laura Chériaux , Juraté Davoust , Kim-Thanh Ong , Marie Cotillon , Thibault de Groc , Sébastien Le , Nathalie Vergnault , Hélène Sée , Laure Cohen , Alice de Tugny , Nevena Danekova , Marine Mommert-Tripon , Karen Brengel-Pesce , Marko Pokorn , Mojca Kolnik , Tadej Avčin , Tanja Avramoska , Natalija Bahovec , Petra Bogovič , Lidija Kitanovski , Mirijam Nahtigal , Lea Papst , Tina Plankar Srovin , Franc Strle , Anja Srpčič , Katarina Vincek , Michiel van der Flier , Wim J. E. Tissing , Roelie M. Wösten-van Asperen , Sebastiaan J. Vastert , Daniel C. Vijlbrief , Louis J. Bont , Tom F. W. Wolfs , Coco R. Beudeker , Philipp Agyeman , Luregn Schlapbach , Christoph Aebi , Mariama Usman , Stefanie Schlüchter , Verena Wyss , Nina Schöbi , Elisa Zimmermann , Marion Meier , Kathrin Weber , Luregn J. Schlapbach , Eric Giannoni , Martin Stocker , Klara M. Posfay-Barbe , Ulrich Heininger , Sara Bernhard-Stirnemann , Anita Niederer-Loher , Christian Kahlert , Giancarlo Natalucci , Christa Relly , Thomas Riedel , Christoph Berger , Colin Fink , Marie Voice , Leo Calvo-Bado , Michael Steele , Jennifer Holden , Benjamin Evans , Jake Stevens , PETER MATTHEWS , Kyle Billing , Werner Zenz , Alexander Binder , Benno Kohlmaier , Daniela S. Kohlfürst , Nina A. Schweintzger , Christoph Zurl , Susanne Hösele , Manuel Leitner , Lena Pölz , Alexandra Rusu , Glorija Rajic , Bianca Stoiser , Martina Strempfl , Manfred G. Sagmeister , Sebastian Bauchinger , Martin Benesch , Astrid Ceolotto , Ernst Eber , Siegfried Gallistl , Harald Haidl , Almuthe Hauer , Christa Hude , Andreas Kapper , Markus Keldorfer , Sabine Löffler , Tobias Niedrist , Heidemarie Pilch , Andreas Pfleger , Klaus Pfurtscheller , Siegfried Rödl , Andrea Skrabl-Baumgartner , Volker Strenger , Elmar Wallner , Dennie Tempel , Danielle van Keulen , Annelieke M. Strijbosch , Maike K. Tauchert , Ulrich von Both , Laura Kolberg , Patricia Schmied , Irene Alba-Alejandre , Katharina Danhauser , Nikolaus Haas , Florian Hoffmann , Matthias Griese , Tobias Feuchtinger , Sabrina Juranek , Matthias Kappler , Eberhard Lurz , Esther Maier , Karl Reiter , Carola Schoen , Sebastian Schroepf , Shunmay Yeung , Manuel Dewez , David Bath , Elizabeth Fitchett , Fiona Cresswell , Saidykhan Momodou , Effua Usuf , Ebrahim Ndure , Kalifa Bojang , Anna Roca , Isatou Sarr , Malcolm G. Semple , Gail Carson , Peter J. M. Openshaw , Jake Dunning , Laura Merson , Clark D. Russell , David Dorward , Maria Zambon , Richard S. Tedder , Saye Khoo , Lance C. W. Turtle , Tom Solomon , Samreen Ijaz , Tom Fletcher , Emma C. Thomson , Nicholas Price , Judith Breuer , Thushan de Silva , Chloe Donohue , Hayley Hardwick , Lauren Obosi , Sara Clohisey , Andrew Law , Lucy Norris , Sarah Tait , Murray Wham , Richard Clark , Audrey Coutts , Lorna Donnelly , Angie Fawkes , Tammy Gilchrist , Katarzyna Hafezi , Louise MacGillivray , Alan Maclean , Sarah McCafferty , Kirstie Morrice , Lee Murphy , Nicola Wrobel , Victoria Shaw , Katie A. Ahmed , Jane A. Armstrong , Lauren Lett , Shyla Kishore , Helen Brotherton , Lawrence Armstrong , Andrew Mitra , Anna Dall , Kristyna Bohmova , Sheena Logan , Ken Agwuh , Srikanth Chukkambotla , Ingrid DuRand , Duncan Fullerton , Sanjeev Gar , Clive Graham , Tassos Grammatikopoulos , Stuart Hartshorn , Luke Hodgson , Paul Jennings , George Koshy , Tamas Leiner , James Limb , Jeff Little , Elijah Matovu , Fiona McGill , Craig Morris , John Morrice , David Price , Henrik Reschreiter , Tim Reynolds , Paul Whittaker , Thomas Jordan , Clare Irving , Katherine Jack , Maxine Ramsay , Margaret Millar , Barry Milligan , Naomi Hickey , Maggie Connon , Catriona Ward , Laura Beveridge , Susan MacFarlane , Karen Leitch , Claire Bell , Lauren Finlayson , Joy Dawson , Janie Candlish , Laura McGenily , Tara Roome , Cynthia Diaba , Jasmine Player , Natassia Powell , Ruth Howman , Sara Burling , Sharon Floyd , Sarah Farmer , Susie Ferguson , Susan Hope , Lucy Rubick , Rachel Swingler , Emma Collins , Collette Spencer , Amaryl Jones , Barbara Wilson , Diane Armstrong , Mark Birt , Holly Dickinson , Rosemary Harper , Darran Martin , Amy Roff , Sarah Mills , Massimo Palmarini , Surajit Ray , David L. Robertson , Ana da Silva Filipe , Brian J. Willett , David Turner , J. Kenneth Baillie
ANO 2023
TIPO Book
PERIÓDICO Nature
ISSN 0028-0836
DOI 10.1038/s41586-023-05948-2
ADICIONADO EM 2025-08-29

Resumo

In 2022, an unusual increase in children presenting with severe acute hepatitis of unknown aetiology was reported globally. Here, using nucleic acid and serological testing of blood and liver samples from affected children, we show an association between adeno-associated virus 2 (AAV2) and non-A–E hepatitis in children. AAV2 was present at significantly higher titres in children with non-A–E hepatitis compared with controls. Co-infection with a helper virus, human adenovirus (HAdV), was more frequently detected in children with non-A–E hepatitis than in controls. The presence of AAV2 and HAdV DNA in liver tissue suggests that the liver is a site of viral replication. We also identified human leukocyte antigen gene variations associated with susceptibility to non-A–E hepatitis. Our findings suggest that AAV2, in the context of HAdV co-infection and genetic predisposition, may have a role in the aetiology of non-A–E hepatitis in children.

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