After the Double Helix
Rosalind Franklin's Research onTobacco mosaic virus
Bibliographic Data
| ID | 3580677 |
|---|---|
| Authors | Angela N H Creager (0000-0002-7763-6432, Princeton University), Gregory J Morgan (0000-0002-2805-2561, Spring Hill College) |
| Year | 2008 |
| Volume | 99 |
| Issue | 2 |
| Pages | 239-272 |
| Publication date | 2008-06-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Isis (JOURNAL) |
| Journal identifiers | ISSN: 0021-1753 • E-ISSN: 1545-6994 |
| Publisher | University of Chicago Press (PUBLISHER • US) |
| DOI | 10.1086/588626 |
| PMID | 18702397 |
| OpenAlex | W2257371659 |
| Language | EN |
| Citations received | 5 |
| References cited | 36 |
Rosalind Franklin is best known for her informative X-ray diffraction patterns of DNA that provided vital clues for James Watson and Francis Crick's double-stranded helical model. Her scientific career did not end when she left the DNA work at King's College, however. In 1953 Franklin moved to J. D. Bernal's crystallography laboratory at Birkbeck College, where she shifted her focus to the three-dimensional structure of viruses, obtaining diffraction patterns of Tobacco mosaic virus (TMV) of unprecedented detail and clarity. During the next five years, while making significant headway on the structural determination of TMV, Franklin maintained an active correspondence with both Watson and Crick, who were also studying aspects of virus structure. Developments in TMV research during the 1950s illustrate the connections in the emerging field of molecular biology between structural studies of nucleic acids and of proteins and viruses. They also reveal how the protagonists of the "race for the double helix" continued to interact personally and professionally during the years when Watson and Crick's model for the double-helical structure of DNA was debated and confirmed
Base pair · Biology · CLARITY · Crystallography · DNA · Helix (gastropod · Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid · Physics · Tobacco mosaic virus · Virus · Watson · Zoology · Bacteriophages and microbial interactions · Chemistry · Computer Science · Genetics · Molecular Biology · Plant Virus Research Studies
| Unique citing works | 5 |
|---|---|
| Citations per year | 0,31 |
| Citation span | 2010 - 2022 (13) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 4 |