If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans
Bibliographic Data
| ID | 4424985 |
|---|---|
| Authors | Gale E Miller (0000-0002-7217-1082, University of British Columbia Hospital), Gregory E Miller, Edith Chen (0000-0001-6116-2239, University of British Columbia Hospital), Eric S Zhou (0000-0003-1038-8961, University of British Columbia Hospital) |
| Year | 2007 |
| Volume | 133 |
| Issue | 1 |
| Pages | 25-45 |
| Publication date | 2007-01-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychological Bulletin (JOURNAL) |
| Journal identifiers | ISSN: 0033-2909 • E-ISSN: 1939-1455 |
| Publisher | American Psychological Association (APA) (PUBLISHER) |
| DOI | 10.1037/0033-2909.133.1.25 |
| PMID | 17201569 |
| OpenAlex | W2163857054 |
| Language | EN |
| Citations received | 281 |
| References cited | 44 |
The notion that chronic stress fosters disease by activating the hypothalamic-pituitary-adrenocortical (HPA) axis is featured prominently in many theories. The research linking chronic stress and HPA function is contradictory, however, with some studies reporting increased activation, and others reporting the opposite. This meta-analysis showed that much of the variability is attributable to stressor and person features. Timing is an especially critical element, as hormonal activity is elevated at stressor onset but reduces as time passes. Stressors that threaten physical integrity, involve trauma, and are uncontrollable elicit a high, flat diurnal profile of cortisol secretion. Finally, HPA activity is shaped by a person's response to the situation; it increases with subjective distress but is lower in persons with posttraumatic stress disorder
Chronic stress · Corticosterone · Developmental psychology · Distress · Hormone · Stressor · Clinical Psychology · Endocrinology · Health, psychology, and well-being · Internal Medicine · Medicine · Neuroscience · Optimism, Hope, and Well-being · Psychology · Stress Responses and Cortisol
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| Unique citing works | 281 |
|---|---|
| Citations per year | 15,61 |
| Citation span | 2008 - 2026 (19) |
| Citation velocity | current |
| Highly cited | Yes |
| Citation types | Neutral: 248 |