The Dynamics ofWertbestimmung

Bibliographic Data

ID4516194
AuthorsAxel C Hüntelmann (0000-0002-7321-1541, Heidelberg University, corresponding author)
Year2008
Volume21
Issue2
Pages229-252
Publication date2008-06-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueScience in Context (JOURNAL)
Journal identifiersISSN: 0269-8897 • E-ISSN: 1474-0664
PublisherCambridge University Press (CUP) (PUBLISHER)
DOI10.1017/s0269889708001701
PMID18831138
OpenAlexW2125762319
LanguageEN
Citations received3
References cited23

ArgumentThe procedure ofWertbestimmungplayed a vital role in the implementation of serum therapy and the standardization of mass-produced pharmaceuticals. In fin-de-siècle Germany, a legal framework was put in place to guarantee serum quality and safety and to minimize any associated public health risks. Because the sera were biological remedies, it was difficult to produce them in uniform quality and the procedure ofWertbestimmung, i.e. determining the potency of the serum based on an objective and comparable value, was extremely complex. Various agents such as bacteria cultures, serum hosts, or test animals had to be regulated. In the years after 1895, numerous efforts to stabilize the procedures ofWertbestimmungwere undertaken by serum producers and members of the state-run survey institute responsible for overseeing serum production. Despite efforts to stabilize the framework and to generate a reliable reference system, the framework's environment and agents were in constant flux: new producers entered the market and procedures were expanded to include other biologicals as well. The article describes the dynamics involved in the sustained efforts to maintain a stable framework in the face of constant alterations between 1895 and the 1920s

Historical Medical Research and Treatments · Medical History and Research · Psychology

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