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A case study of possible differential diagnoses of a medieval skeleton from Denmark

Leprosy, Ergotism, Treponematosis, Sarcoidosis or Smallpox

Bibliographic Data

ID4676730
AuthorsM Lefort, Marie Magdeleine Lefort (University of Copenhagen), Pia Bennike (University of Copenhagen, corresponding author)
Year2007
Volume17
Issue4
Pages337-349
Publication date2007-07-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Osteoarchaeology (JOURNAL)
Journal identifiersISSN: 1047-482X • E-ISSN: 1099-1212
PublisherWiley (PUBLISHER • GB)
DOI10.1002/oa.905
OpenAlexW1999926644
LanguageEN
Citations received7
References cited10

This paper uses macroscopic and radiological examinations to provide differential diagnoses of pathological lesions in the skeleton of a young woman, 20-25 years of age, which triggered the Danish palaeopathologist Vilhelm Møller-Christensen's interest in leprosy. The skeleton was incomplete, but the majority of bones of the upper body, as well as the skull, were present. The pathological changes consisted of medullary and cortical lytic foci, periosteal reaction and enhanced cortical density. The lesions were most extensive on the left side, especially around the elbow, wrist and scapula. Treponematosis, leprosy, smallpox, ergotism, rheumatoid arthritis, tuberculosis and sarcoidosis are all reviewed with regard to bone and joint pathology and their likelihood of being the correct diagnosis. We concluded that the most plausible diagnosis is treponematosis, but neither sarcoidosis nor smallpox can be completely excluded. Copyright (c) 2007 John Wiley & Sons, Ltd

Differential diagnosis · Leprosy · Paleopathology · Pathology · Periostitis · Sarcoidosis · Smallpox · Syphilis · Treponematosis · Tuberculosis · Dermatological diseases and infestations · Forensic Anthropology and Bioarchaeology Studies · Leprosy Research and Treatment · Medicine · Dermatology

  • Palaeopathology

    Open Access•Charlotte A Roberts, Charlotte Roberts•Encyclopedia of Global Archaeology•2020

  • Biological and social implications of a medieval burial from Cyprus for understanding leprosy in the past

    Open Access•Brenda J Baker, Katelyn L Bolhofner•International Journal of…•2014

  • Unforgotten

    Open Access•Felicia Fricke, J E Laffoon et al.•Journal of Archaeological Science…•2021

  • A case of osteomyelitis variolosa from Roman Britain, and the introduction of smallpox to the Roman world

    Open Access•Haoyue Zhao, Zhao Hui-feng et al.•Journal of Roman Archaeology•2025

  • Periostitis and osteolysis in a medieval skeleton from South‐West Hungary

    Open Access•T Christensen, Manuel Martínez‐Lavín et al.•International Journal of…•2011

  • On the mystery cloud of AD 536, a crisis in dispute and epidemic ergotism

    Open Access•Lennart Bondeson, Tobias Bondesson•Danish Journal of Archaeology•2014

  • Volcanoes, medicine, and monasticism

    Open Access•J W Walser, Steinunn Kristjánsdóttir et al.•International Journal of…•2019

  • Pre‐Columbian treponemal disease from 14th century AD Safed, Israel, and implications for the medieval eastern Mediterranean

    Open Access•P D Mitchell•American Journal of Physical…•2003

  • Osteological evidence for smallpox

    Open Access•Mary Jackes, M K Jackes•American Journal of Physical…•1983

  • The rhinomaxillary syndrome in leprosy

    Open Access•Johs G Andersen, Keith Manchester•International Journal of…•1992

Unique citing works7
Citations per year0,47
Citation span2011 - 2025 (15)
Citation velocityrecent
Highly citedNo
Citation typesNeutral: 7

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