Genetic footprints of assortative mating in the Japanese population
Bibliographic Data
| ID | 4695866 |
|---|---|
| Authors | Kenichi Yamamoto (0000-0001-9594-7050, The University of Osaka), Kyuto Sonehara (0000-0002-4536-1761, The University of Osaka), Shinichi Namba (0000-0002-7486-3146, The University of Osaka), Takahiro Konuma (The University of Osaka), Hironori Masuko (0000-0002-5917-7973, University of Tsukuba), Satoru Miyawaki (0000-0001-6369-3391, The University of Tokyo), The Biobank Japan Project (The University of Tokyo), Yoichiro Kamatani (0000-0001-8748-5597, University of Tsukuba), Nobuyuki Hizawa (University of Tsukuba), Keiichi Ozono (0000-0002-6517-8825, The University of Queensland), Loic Yengo (0000-0002-4272-9305, The University of Queensland), Yuzuru Okada (0000-0002-0311-8472, RIKEN Center for Integrative Medical Sciences, corresponding author) |
| Year | 2022 |
| Volume | 7 |
| Issue | 1 |
| Pages | 65-73 |
| Publication date | 2022-09-22 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Nature Human Behaviour (JOURNAL) |
| Journal identifiers | ISSN: 2397-3374 • E-ISSN: 2397-3374 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1038/s41562-022-01438-z |
| PMID | 36138222 |
| OpenAlex | W4296690670 |
| Language | EN |
| Citations received | 2 |
| References cited | 62 |
Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating partners. Detecting the evidence of AM has been challenging due to the lack of large-scale datasets that include phenotypic data on both partners, especially in populations of non-European ancestries. Gametic phase disequilibrium between trait-associated alleles is a signature of parental AM on a polygenic trait, which can be detected even without partner data. Here, using polygenic scores for 81 traits in the Japanese population using BioBank Japan Project genome-wide association studies data (n = 172,270), we found evidence of AM on the liability to type 2 diabetes and coronary artery disease, as well as on dietary habits. In cross-population comparison using United Kingdom Biobank data (n = 337,139) we found shared but heterogeneous impacts of AM between populations
Allele · Assortative mating · Biobank · Biology · Evolutionary biology · Gene · Haplotype · Linkage Disequilibrium · Mating · Population · Trait · Demography · Genetic and phenotypic traits in livestock · Genetic Associations and Epidemiology · Genetic Mapping and Diversity in Plants and Animals · Genetics
The UK Biobank resource with deep phenotyping and genomic data
Gcta
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| Citations per year | 0.5 |
|---|---|
| Citation span | 2022 - 2025 (4) |
| Highly cited | No |